The need to unravel the twisted nature of the Borrelia burgdorferi sensu lato complex across Europe.
Microbiology (Reading)
; 166(5): 428-435, 2020 05.
Article
en En
| MEDLINE
| ID: mdl-32125267
ABSTRACT
Lyme borreliosis is a vector-borne infection caused by bacteria under the Borrelia burgdorferi sensu lato complex, both in Europe and North America. Differential gene expression at different times throughout its infectious cycle allows the spirochete to survive very diverse environments within different mammalian hosts as well as the tick vector. To date, the vast majority of data about spirochetal proteins and their functions are from genetic studies carried out on North American strains of a single species, i.e. B. burgdorferi sensu stricto. The whole-genome sequences recently obtained for several European species/strains make it feasible to adapt and use genetic techniques to study inherent differences between them. This review highlights the crucial need to undertake independent studies of genospecies within Europe, given their varying genetic content and pathogenic potential, and differences in clinical manifestation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedad de Lyme
/
Regulación Bacteriana de la Expresión Génica
/
Borrelia burgdorferi
/
Factores de Virulencia
Límite:
Animals
/
Humans
País/Región como asunto:
America do norte
/
Europa
Idioma:
En
Revista:
Microbiology (Reading)
Asunto de la revista:
MICROBIOLOGIA
Año:
2020
Tipo del documento:
Article
País de afiliación:
República Checa