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Association between ZNF184 and symptoms of Parkinson's disease in southern Chinese.
Zhang, Bei; Cui, Can; Yu, Hongxiang; Li, Gang.
Afiliación
  • Zhang B; Department of Neurology, East Hospital, Tongji University School of Medicine, 1800 Yuntai Road, Shanghai, 200123, China.
  • Cui C; Department of Neurology, East Hospital, Tongji University School of Medicine, 1800 Yuntai Road, Shanghai, 200123, China.
  • Yu H; Department of Neurology, East Hospital, Tongji University School of Medicine, 1800 Yuntai Road, Shanghai, 200123, China.
  • Li G; Department of Neurology, East Hospital, Tongji University School of Medicine, 1800 Yuntai Road, Shanghai, 200123, China. ligang@tongji.edu.cn.
Neurol Sci ; 41(8): 2121-2126, 2020 Aug.
Article en En | MEDLINE | ID: mdl-32125537
STUDY OBJECTIVES: The aim was to investigate the association between ZNF184 and symptoms of Parkinson's disease (PD) in southern Chinese. METHODS: A total of 241 PD patients were recruited in this study. All patients were evaluated by Sniffin' Sticks 16 (SS-16), Hamilton anxiety rating scale and Hamilton depression rating scale, 39-item Parkinson's disease Questionnaire (PDQ-39) and MDS-Unified PD Rating Scale (MDS-UPDRS). Symptoms were also recorded. RESULTS: There was association of rapid eye movement sleep behavior disorder (RBD) under additive, dominant and overdominant model (p 0.039, additive; p 0.028, dominant; p 0.044, overdominant). We also found the association of excessive daytime sleepiness under the dominant model, the association of urgent urination or urinary incontinence under the recessive model and the association of sensitive to hot under the overdominant model (excessive daytime sleepiness: p 0.032, dominant; p 0.038, dominant; urgent urination or urgent incontinence: p 0.027, recessive; sensitive to hot: p, 0.027, overdominant). CONCLUSIONS: ZNF184 rs9468199 was associated with the presence of RBD, excessive daytime sleepiness, urgent urination or urgent incontinence and sensitive to hot.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Trastorno de la Conducta del Sueño REM / Trastornos de Somnolencia Excesiva Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Neurol Sci Asunto de la revista: NEUROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Trastorno de la Conducta del Sueño REM / Trastornos de Somnolencia Excesiva Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Neurol Sci Asunto de la revista: NEUROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: China