Your browser doesn't support javascript.
loading
Impact of Early Tranexamic Acid Administration on Overall Blood Product Utilization at 24 Hours.
Douglas, Alisha; Faviere, Donna; Gallo, Amber; VanderSchaaf, Ashley; Wall, Ward; Wilson, Kayla; Young, Ashley.
Afiliación
  • Douglas A; Department of Trauma Services (Mss Douglas and Gallo and Dr Wall), Department of Emergency Medicine (Mss Faviere and Young), Department of Perioperative Services (Ms VanderSchaaf), Department of Emergency Medicine/Pharmacy (Dr Wilson), Lakeland Regional Health, Lakeland, Florida.
J Trauma Nurs ; 27(2): 66-70, 2020.
Article en En | MEDLINE | ID: mdl-32132483
ABSTRACT
Antifibrinolytics have demonstrated a mortality benefit in trauma patients when utilized early after injury. In line with recent literature, the authors hypothesize that early tranexamic acid (TXA) administration will decrease overall blood product administration at 24 hr. This is a retrospective cohort evaluation of 65 trauma patients admitted and discharged between May 1, 2015, and December 31, 2017, who received packed red blood cells (PRBCs) and TXA within 3 hr following injury. The primary outcome was overall PRBC utilization at 24 hr when TXA was administered less than 1 hr of injury compared with 1-3 hr of injury. A subgroup analysis compared PRBC usage at 24 hr when PRBC to TXA administration time was less than 30 min compared with 30 min or more. During the study time, 15 patients received TXA early, less than 1 hr from injury, and 50 patients received TXA within 1-3 hr of injury. Patients received a median of 7 units of PRBCs in the early group and 8 units in the standard group (p = .64) at 24 hr. Patients who received TXA less than 30 min after first PRBC received a median of 6 units at 24 hr compared with 9 units when PRBC to TXA time was 30 min or more (p = .014). There was no difference in PRBCs at 24 hr in patients who received TXA early compared with 1-3 hr from injury. There was a significant increase in PRBC requirement at 24 hr when patients received TXA 30 min or more from first PRBC. Further inquiry into the optimal timing of TXA administrated is needed.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ácido Tranexámico / Heridas y Lesiones / Transfusión Sanguínea / Antifibrinolíticos Tipo de estudio: Observational_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: J Trauma Nurs Asunto de la revista: ENFERMAGEM / TRAUMATOLOGIA Año: 2020 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ácido Tranexámico / Heridas y Lesiones / Transfusión Sanguínea / Antifibrinolíticos Tipo de estudio: Observational_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: J Trauma Nurs Asunto de la revista: ENFERMAGEM / TRAUMATOLOGIA Año: 2020 Tipo del documento: Article