Your browser doesn't support javascript.
loading
Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis.
Nabais, Marta F; Lin, Tian; Benyamin, Beben; Williams, Kelly L; Garton, Fleur C; Vinkhuyzen, Anna A E; Zhang, Futao; Vallerga, Costanza L; Restuadi, Restuadi; Freydenzon, Anna; Zwamborn, Ramona A J; Hop, Paul J; Robinson, Matthew R; Gratten, Jacob; Visscher, Peter M; Hannon, Eilis; Mill, Jonathan; Brown, Matthew A; Laing, Nigel G; Mather, Karen A; Sachdev, Perminder S; Ngo, Shyuan T; Steyn, Frederik J; Wallace, Leanne; Henders, Anjali K; Needham, Merrilee; Veldink, Jan H; Mathers, Susan; Nicholson, Garth; Rowe, Dominic B; Henderson, Robert D; McCombe, Pamela A; Pamphlett, Roger; Yang, Jian; Blair, Ian P; McRae, Allan F; Wray, Naomi R.
Afiliación
  • Nabais MF; 1Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072 Australia.
  • Lin T; 2University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, Devon EX2 5DW UK.
  • Benyamin B; 1Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072 Australia.
  • Williams KL; 1Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072 Australia.
  • Garton FC; 3Australian Centre for Precision Health, University of South Australia Cancer Research Institute, School of Health Sciences, University of South Australia, Adelaide, SA 5001 Australia.
  • Vinkhuyzen AAE; 4Centre for Motor Neuron Disease Research, Macquarie University, Sydney, NSW 2109 Australia.
  • Zhang F; 1Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072 Australia.
  • Vallerga CL; 1Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072 Australia.
  • Restuadi R; 1Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072 Australia.
  • Freydenzon A; 1Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072 Australia.
  • Zwamborn RAJ; 1Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072 Australia.
  • Hop PJ; 1Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072 Australia.
  • Robinson MR; 5Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, 3584 CG Netherlands.
  • Gratten J; 5Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, 3584 CG Netherlands.
  • Visscher PM; 1Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072 Australia.
  • Hannon E; 1Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072 Australia.
  • Mill J; 6Mater Research Institute, The University of Queensland, Brisbane, QLD 4101 Australia.
  • Brown MA; 1Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072 Australia.
  • Laing NG; 7Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072 Australia.
  • Mather KA; 2University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, Devon EX2 5DW UK.
  • Sachdev PS; 2University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, Devon EX2 5DW UK.
  • Ngo ST; 8Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF UK.
  • Steyn FJ; 9Australian Translational Genomics Centre, Queensland University of Technology, Brisbane, QLD 4102 Australia.
  • Wallace L; 10The Centre for Medical Research, Faculty of Health and Medical Sciences, The University of Western Australia, Nedlands, WA 6009 Australia.
  • Henders AK; 11Harry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands, WA 6009 Australia.
  • Needham M; 12Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW 2031 Australia.
  • Veldink JH; 13Neuroscience Research Australia Institute, Randwick, NSW 2031 Australia.
  • Mathers S; 12Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW 2031 Australia.
  • Nicholson G; 14Neuropsychiatric Institute, The Prince of Wales Hospital, University of New South Wales, Randwick, NSW 2031 Australia.
  • Rowe DB; 7Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072 Australia.
  • Henderson RD; 15The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072 Australia.
  • McCombe PA; 16Centre for Clinical Research, The University of Queensland, Brisbane, QLD 4019 Australia.
  • Pamphlett R; 15The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072 Australia.
  • Yang J; 16Centre for Clinical Research, The University of Queensland, Brisbane, QLD 4019 Australia.
  • Blair IP; 1Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072 Australia.
  • McRae AF; 1Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072 Australia.
  • Wray NR; 17Fiona Stanley Hospital, Perth, WA 6150 Australia.
NPJ Genom Med ; 5: 10, 2020.
Article en En | MEDLINE | ID: mdl-32140259
ABSTRACT
We conducted DNA methylation association analyses using Illumina 450K data from whole blood for an Australian amyotrophic lateral sclerosis (ALS) case-control cohort (782 cases and 613 controls). Analyses used mixed linear models as implemented in the OSCA software. We found a significantly higher proportion of neutrophils in cases compared to controls which replicated in an independent cohort from the Netherlands (1159 cases and 637 controls). The OSCA MOMENT linear mixed model has been shown in simulations to best account for confounders. When combined in a methylation profile score, the 25 most-associated probes identified by MOMENT significantly classified case-control status in the Netherlands sample (area under the curve, AUC = 0.65, CI95% = [0.62-0.68], p = 8.3 × 10-22). The maximum AUC achieved was 0.69 (CI95% = [0.66-0.71], p = 4.3 × 10-34) when cell-type proportion was included in the predictor.
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: NPJ Genom Med Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: NPJ Genom Med Año: 2020 Tipo del documento: Article