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Lactic acidosis induces resistance to the pan-Akt inhibitor uprosertib in colon cancer cells.
Barnes, Emily M E; Xu, Yitao; Benito, Adrian; Herendi, Lili; Siskos, Alexandros P; Aboagye, Eric O; Nijhuis, Anke; Keun, Hector C.
Afiliación
  • Barnes EME; Cancer Metabolism & Systems Toxicology Group, Division of Cancer, Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital Campus, London, W12 0NN, UK.
  • Xu Y; Cancer Metabolism & Systems Toxicology Group, Division of Cancer, Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital Campus, London, W12 0NN, UK.
  • Benito A; Cancer Metabolism & Systems Toxicology Group, Division of Cancer, Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital Campus, London, W12 0NN, UK.
  • Herendi L; Cancer Metabolism & Systems Toxicology Group, Division of Cancer, Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital Campus, London, W12 0NN, UK.
  • Siskos AP; Cancer Metabolism & Systems Toxicology Group, Division of Cancer, Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital Campus, London, W12 0NN, UK.
  • Aboagye EO; Cancer Imaging Centre, Imperial College London, Hammersmith Hospital Campus, London, W12 0NN, UK.
  • Nijhuis A; Cancer Metabolism & Systems Toxicology Group, Division of Cancer, Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital Campus, London, W12 0NN, UK.
  • Keun HC; Cancer Metabolism & Systems Toxicology Group, Division of Cancer, Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital Campus, London, W12 0NN, UK. h.keun@imperial.ac.uk.
Br J Cancer ; 122(9): 1298-1308, 2020 04.
Article en En | MEDLINE | ID: mdl-32152504
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Acidosis Láctica / Neoplasias del Colon / Resistencia a Antineoplásicos / Proteína Oncogénica v-akt Límite: Humans Idioma: En Revista: Br J Cancer Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Acidosis Láctica / Neoplasias del Colon / Resistencia a Antineoplásicos / Proteína Oncogénica v-akt Límite: Humans Idioma: En Revista: Br J Cancer Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido