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Targeted inhibition of gut bacterial ß-glucuronidase activity enhances anticancer drug efficacy.
Bhatt, Aadra P; Pellock, Samuel J; Biernat, Kristen A; Walton, William G; Wallace, Bret D; Creekmore, Benjamin C; Letertre, Marine M; Swann, Jonathan R; Wilson, Ian D; Roques, Jose R; Darr, David B; Bailey, Sean T; Montgomery, Stephanie A; Roach, Jeffrey M; Azcarate-Peril, M Andrea; Sartor, R Balfour; Gharaibeh, Raad Z; Bultman, Scott J; Redinbo, Matthew R.
Afiliación
  • Bhatt AP; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290.
  • Pellock SJ; Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7555.
  • Biernat KA; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7555.
  • Walton WG; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290.
  • Wallace BD; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290.
  • Creekmore BC; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290.
  • Letertre MM; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290.
  • Swann JR; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290.
  • Wilson ID; Computational and Systems Medicine, Department of Surgery & Cancer, Imperial College London, SW7 2AZ London, United Kingdom.
  • Roques JR; Computational and Systems Medicine, Department of Surgery & Cancer, Imperial College London, SW7 2AZ London, United Kingdom.
  • Darr DB; Computational and Systems Medicine, Department of Surgery & Cancer, Imperial College London, SW7 2AZ London, United Kingdom.
  • Bailey ST; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
  • Montgomery SA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
  • Roach JM; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
  • Azcarate-Peril MA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
  • Sartor RB; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7525.
  • Gharaibeh RZ; Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7555.
  • Bultman SJ; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7555.
  • Redinbo MR; Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7555.
Proc Natl Acad Sci U S A ; 117(13): 7374-7381, 2020 03 31.
Article en En | MEDLINE | ID: mdl-32170007

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Microbioma Gastrointestinal / Glucuronidasa Límite: Animals / Female / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2020 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Microbioma Gastrointestinal / Glucuronidasa Límite: Animals / Female / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2020 Tipo del documento: Article