Retinoid X receptor agonists attenuates cardiomyopathy in streptozotocin-induced type 1 diabetes through LKB1-dependent anti-fibrosis effects.

Chai, Dajun; Lin, Xiaoyan; Zheng, Qiaowen; Xu, Changsheng; Xie, Hong; Ruan, Qinyun; Lin, Jinxiu; Liu, Jie; Zeng, Jinzhang

Chai, Dajun; Lin, Xiaoyan; Zheng, Qiaowen; Xu, Changsheng; Xie, Hong; Ruan, Qinyun; Lin, Jinxiu; Liu, Jie; Zeng, Jinzhang.

Afiliación

Chai D; Cardiovascular Department, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China.
Lin X; Echocardiological Department, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China.
Zheng Q; Cardiovascular Department, Fuqing City Hospital, Fuzhou 350005, China.
Xu C; Cardiovascular Department, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China.
Xie H; Cardiovascular Department, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China.
Ruan Q; Echocardiological Department, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China.
Lin J; Cardiovascular Department, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China.
Liu J; School of Pharmacy College, Xiamen University, Xiamen 361102, China.
Zeng J; School of Pharmacy College, Xiamen University, Xiamen 361102, China.

Clin Sci (Lond) ; 134(6): 609-628, 2020 03 27.

Article en En | MEDLINE | ID: mdl-32175563

Asunto(s)

Bexaroteno/administración & dosificación; Cardiomiopatías/tratamiento farmacológico; Diabetes Mellitus Tipo 1/complicaciones; Proteínas Serina-Treonina Quinasas/metabolismo; Receptores X Retinoide/agonistas; Quinasas de la Proteína-Quinasa Activada por el AMP; Animales; Cardiomiopatías/etiología; Cardiomiopatías/genética; Cardiomiopatías/metabolismo; Fibrosis/tratamiento farmacológico; Fibrosis/etiología; Fibrosis/genética; Fibrosis/metabolismo; Humanos; Masculino; Proteínas Serina-Treonina Quinasas/genética; Ratas; Ratas Sprague-Dawley; Receptores X Retinoide/genética; Receptores X Retinoide/metabolismo; Proteínas Quinasas S6 Ribosómicas 70-kDa/genética; Proteínas Quinasas S6 Ribosómicas 70-kDa/metabolismo; Estreptozocina

Palabras clave

LKB1; Retinoid X receptor; anti-fibrosis; diabetic cardiomyopathy

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Serina-Treonina Quinasas / Receptores X Retinoide / Diabetes Mellitus Tipo 1 / Bexaroteno / Cardiomiopatías Tipo de estudio: Etiology_studies Límite: Animals / Humans / Male Idioma: En Revista: Clin Sci (Lond) Año: 2020 Tipo del documento: Article País de afiliación: China

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google