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Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned.
Choi, Ryan; Hulverson, Matthew A; Huang, Wenlin; Vidadala, Rama S R; Whitman, Grant R; Barrett, Lynn K; Schaefer, Deborah A; Betzer, Dana P; Riggs, Michael W; Doggett, J Stone; Hemphill, Andrew; Ortega-Mora, Luis Miguel; McCloskey, Molly C; Arnold, Samuel L M; Hackman, Robert C; Marsh, Kennan C; Lynch, James J; Freiberg, Gail M; Leroy, Bruce E; Kempf, Dale J; Choy, Robert K M; de Hostos, Eugenio L; Maly, Dustin J; Fan, Erkang; Ojo, Kayode K; Van Voorhis, Wesley C.
Afiliación
  • Choi R; Department of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington, Seattle, WA 98109, USA.
  • Hulverson MA; Department of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington, Seattle, WA 98109, USA.
  • Huang W; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Vidadala RSR; Department of Chemistry, University of Washington, Seattle, WA 98195, USA.
  • Whitman GR; Department of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington, Seattle, WA 98109, USA.
  • Barrett LK; Department of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington, Seattle, WA 98109, USA.
  • Schaefer DA; School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, AZ 85721, USA.
  • Betzer DP; School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, AZ 85721, USA.
  • Riggs MW; School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, AZ 85721, USA.
  • Doggett JS; VA Portland Health Care System, Portland, OR 97239, USA.
  • Hemphill A; Institute of Parasitology, Vetsuisse Faculty, University of Bern, Länggass-Strasse 122, CH-3012 Bern, Switzerland.
  • Ortega-Mora LM; SALUVET, Animal Health Department, Faulty of Veterinary Sciences, Complutense University of Madrid, Madrid, Spain.
  • McCloskey MC; Department of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington, Seattle, WA 98109, USA.
  • Arnold SLM; Department of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington, Seattle, WA 98109, USA.
  • Hackman RC; Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Pathology, University of Washington, Seattle, WA 98195, USA; Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.
  • Marsh KC; Research and Development, AbbVie, Inc, North Chicago, IL 60064, USA.
  • Lynch JJ; Research and Development, AbbVie, Inc, North Chicago, IL 60064, USA.
  • Freiberg GM; Research and Development, AbbVie, Inc, North Chicago, IL 60064, USA.
  • Leroy BE; Research and Development, AbbVie, Inc, North Chicago, IL 60064, USA.
  • Kempf DJ; Research and Development, AbbVie, Inc, North Chicago, IL 60064, USA.
  • Choy RKM; PATH, San Francisco, CA 94108 USA.
  • de Hostos EL; PATH, San Francisco, CA 94108 USA.
  • Maly DJ; Department of Chemistry, University of Washington, Seattle, WA 98195, USA.
  • Fan E; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Ojo KK; Department of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington, Seattle, WA 98109, USA.
  • Van Voorhis WC; Department of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington, Seattle, WA 98109, USA. Electronic address: wesley@uw.edu.
Int J Parasitol ; 50(5): 413-422, 2020 05.
Article en En | MEDLINE | ID: mdl-32224121
ABSTRACT
Bumped Kinase Inhibitors, targeting Calcium-dependent Protein Kinase 1 in apicomplexan parasites with a glycine gatekeeper, are promising new therapeutics for apicomplexan diseases. Here we will review advances, as well as challenges and lessons learned regarding efficacy, safety, and pharmacology that have shaped our selection of pre-clinical candidates.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Apicomplexa / Coccidiosis / Inhibidores de Proteínas Quinasas Límite: Animals / Humans Idioma: En Revista: Int J Parasitol Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Apicomplexa / Coccidiosis / Inhibidores de Proteínas Quinasas Límite: Animals / Humans Idioma: En Revista: Int J Parasitol Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos