Effect of periodontal therapy on adipokine biomarkers in overweight.
J Clin Periodontol
; 47(7): 842-850, 2020 07.
Article
en En
| MEDLINE
| ID: mdl-32248552
ABSTRACT
AIM:
The aim of this study was to evaluate the effect of non-surgical periodontal therapy on circulating levels of the systemic inflammation-associated biomarkers orosomucoid (ORM), high-sensitivity C-reactive protein (hsCRP), chemerin, and retinol-binding protein 4 (RBP4) in overweight or normal-weight patients with periodontitis at 27.5 months after therapy. MATERIALS ANDMETHODS:
This exploratory subanalysis includes patients from the ABPARO-trial (ClinicalTrials.gov NCT00707369). The per-protocol collective provided untreated periodontitis patients with high (≥28 kg/m2 ) or moderate (21-24 kg/m2 ) BMI. Out of the per-protocol collective, 80 patients were randomly selected and stratified for BMI group, sex, and treatment group (antibiotics/placebo), resulting in 40 overweight and normal-weight patients. Patients received non-surgical periodontal therapy and maintenance at 3-month intervals. Plasma samples from baseline and 27.5 months following initial treatment were used to measure the concentrations of ORM, hsCRP, chemerin, and RBP4.RESULTS:
At the 27.5-month examination, ORM and hsCRP decreased noticeably in the overweight group (ORM p = .001, hsCRP p = .004) and normal-weight patients (ORM p = .007, hsCRP p < .001). Chemerin decreased in the overweight group (p = .048), and RBP4 concentrations remained stable.CONCLUSION:
Non-surgical periodontal therapy reduced systemically elevated inflammation-associated biomarkers in periodontitis patients. These improvements were more pronounced in overweight patients than in normal-weight patients.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Periodontitis
/
Adipoquinas
Tipo de estudio:
Clinical_trials
/
Guideline
Límite:
Humans
Idioma:
En
Revista:
J Clin Periodontol
Año:
2020
Tipo del documento:
Article
País de afiliación:
Alemania