Spermine synthesis inhibitor blocks 25-hydroxycholesterol-induced- apoptosis via SREBP2 upregulation in DLD-1 cell spheroids.

Kakimoto, Miku; Yamamoto, Hideya; Tanaka, Arowu R

Kakimoto, Miku; Yamamoto, Hideya; Tanaka, Arowu R.

Afiliación

Kakimoto M; Laboratory of Physiology and Morphology, Department of Life Sciences, School of Pharmacy, Yasuda Women's University, 6-13-1 Yasuhigashi, Asaminami Ward, Hiroshima City, Hiroshima, 731-0153, Japan.
Yamamoto H; Laboratory of Physiology and Morphology, Department of Life Sciences, School of Pharmacy, Yasuda Women's University, 6-13-1 Yasuhigashi, Asaminami Ward, Hiroshima City, Hiroshima, 731-0153, Japan.
Tanaka AR; Laboratory of Physiology and Morphology, Department of Life Sciences, School of Pharmacy, Yasuda Women's University, 6-13-1 Yasuhigashi, Asaminami Ward, Hiroshima City, Hiroshima, 731-0153, Japan.

Biochem Biophys Rep ; 22: 100754, 2020 Jul.

Article en En | MEDLINE | ID: mdl-32258442

Palabras clave

25-HC, 25-hydroxycholesterol; 25-Hydroxycholesterol; APCHA; APCHA, N-(3-Aminopropyl)cyclohexylamine; DFMO; DFMO, difluoromethylornithine; HMG-CoA, 3-hydroxy-3-methylglutaryl-coenzyme A; INSIG, insulin inducing gene; MTT, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide; Polyamine; S1P, site-1 protease; S2P, site-2 protease; SCAP, SREBP cleavage activating protein; SRE, sterol response element; SREBP2; SREBP2, sterol regulatory element binding protein 2; poly-HEMA, poly-(2-hydroxyethyl methacrylate)

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Biochem Biophys Rep Año: 2020 Tipo del documento: Article País de afiliación: Japón

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