Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity.

Ngo, Tony; Stephens, Bryan S; Gustavsson, Martin; Holden, Lauren G; Abagyan, Ruben; Handel, Tracy M; Kufareva, Irina

Ngo, Tony; Stephens, Bryan S; Gustavsson, Martin; Holden, Lauren G; Abagyan, Ruben; Handel, Tracy M; Kufareva, Irina.

Afiliación

Ngo T; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America.
Stephens BS; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America.
Gustavsson M; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America.
Holden LG; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America.
Abagyan R; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America.
Handel TM; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America.
Kufareva I; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America.

PLoS Biol ; 18(4): e3000656, 2020 04.

Article en En | MEDLINE | ID: mdl-32271748

Asunto(s)

Quimiocina CXCL12/química; Quimiocina CXCL12/metabolismo; Receptores CXCR4/química; Receptores CXCR4/metabolismo; Animales; Sitios de Unión; Western Blotting; Quimiocina CXCL12/genética; Cisteína/química; Cisteína/genética; Disulfuros/química; Citometría de Flujo; Células HEK293; Humanos; Insectos/citología; Modelos Moleculares; Mutación; Conformación Proteica; Dominios y Motivos de Interacción de Proteínas; Receptores CXCR4/genética; beta-Arrestinas/metabolismo

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Receptores CXCR4 / Quimiocina CXCL12 Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: PLoS Biol Asunto de la revista: BIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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