Bone formation in axial spondyloarthritis: Is disease modification possible?
Best Pract Res Clin Rheumatol
; 33(6): 101491, 2019 12.
Article
en En
| MEDLINE
| ID: mdl-32305314
ABSTRACT
Axial spondyloarthritis (SpA) is a chronic disease characterised by new bone formation (NBF) in the axial skeleton as well as at peripheral entheseal sites. NBF is thought to arise in areas of previous inflammation or osteitis visualised on MRI, with mechanical stress playing a role in disease pathogenesis. The interface between bone and immune cells is complex with the RANKL-OPG system being key to NBF. The IL-17/23 axis and other cytokines such as TNFα and MIF are thought to play a central role. The transition from inflammation to NBF is mediated via the Wnt, BMP and Hedgehog signalling pathways. An altered microbiome has been reported in SpA, which is a potential trigger of NBF in SpA. There is now data to show that treatment with TNF inhibitors prevents NBF and hence modifies disease progression. More research into identifying newer targets for disease modification is needed to alter the course of the disease.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Osteogénesis
/
Espondiloartritis
Límite:
Humans
Idioma:
En
Revista:
Best Pract Res Clin Rheumatol
Asunto de la revista:
REUMATOLOGIA
Año:
2019
Tipo del documento:
Article