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Regional metabolic signatures in the Ndufs4(KO) mouse brain implicate defective glutamate/α-ketoglutarate metabolism in mitochondrial disease.
Johnson, Simon C; Kayser, Ernst-Bernhard; Bornstein, Rebecca; Stokes, Julia; Bitto, Alessandro; Park, Kyung Yeon; Pan, Amanda; Sun, Grace; Raftery, Daniel; Kaeberlein, Matt; Sedensky, Margaret M; Morgan, Philip G.
Afiliación
  • Johnson SC; Department of Neurology, University of Washington, Seattle, WA 98105, USA; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98105, USA; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA 98101, USA.
  • Kayser EB; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA 98101, USA.
  • Bornstein R; Department of Pathology, University of Washington, Seattle, WA 98105, USA.
  • Stokes J; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98105, USA.
  • Bitto A; Department of Pathology, University of Washington, Seattle, WA 98105, USA.
  • Park KY; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA 98101, USA.
  • Pan A; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA 98101, USA.
  • Sun G; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA 98101, USA.
  • Raftery D; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98105, USA; Department of Chemistry, University of Washington, Seattle, WA 98109, United States.
  • Kaeberlein M; Department of Pathology, University of Washington, Seattle, WA 98105, USA.
  • Sedensky MM; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98105, USA; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA 98101, USA.
  • Morgan PG; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98105, USA; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA 98101, USA. Electronic address: pgm4@uw.edu.
Mol Genet Metab ; 130(2): 118-132, 2020 06.
Article en En | MEDLINE | ID: mdl-32331968
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Encéfalo / Enfermedad de Leigh / Ácido Glutámico / Enfermedades Mitocondriales / Complejo I de Transporte de Electrón / Metaboloma / Ácidos Cetoglutáricos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Mol Genet Metab Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA / METABOLISMO Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Encéfalo / Enfermedad de Leigh / Ácido Glutámico / Enfermedades Mitocondriales / Complejo I de Transporte de Electrón / Metaboloma / Ácidos Cetoglutáricos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Mol Genet Metab Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA / METABOLISMO Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos