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Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy.
Tom, Irene; Pham, Victoria C; Katschke, Kenneth J; Li, Wei; Liang, Wei-Ching; Gutierrez, Johnny; Ah Young, Andrew; Figueroa, Isabel; Eshghi, Shadi Toghi; Lee, ChingWei V; Kanodia, Jitendra; Snipas, Scott J; Salvesen, Guy S; Lai, Phillip; Honigberg, Lee; van Lookeren Campagne, Menno; Kirchhofer, Daniel; Baruch, Amos; Lill, Jennie R.
Afiliación
  • Tom I; OMNI Biomarker Development, Genentech, Inc., South San Francisco, CA 94080.
  • Pham VC; Department of Microchemistry, Proteomics & Lipidomics, Genentech, Inc., South San Francisco, CA 94080.
  • Katschke KJ; Department of Immunology, Genentech, Inc., South San Francisco, CA 94080.
  • Li W; Department of Early Discovery Biochemistry, Genentech, Inc., South San Francisco, CA 94080.
  • Liang WC; Department of Antibody Discovery, Genentech, Inc., South San Francisco, CA 94080.
  • Gutierrez J; OMNI Biomarker Development, Genentech, Inc., South San Francisco, CA 94080.
  • Ah Young A; Department of Early Discovery Biochemistry, Genentech, Inc., South San Francisco, CA 94080.
  • Figueroa I; Drug Metabolism, Pharmacokinetics, and Bioanalysis, AbbVie, South San Francisco, CA 94090.
  • Eshghi ST; OMNI Biomarker Development, Genentech, Inc., South San Francisco, CA 94080.
  • Lee CV; Biology Core Support, Gilead Sciences, Foster City, CA 94404.
  • Kanodia J; Clinical and Translational Pharmacology, Theravance Biopharma, Inc., South San Francisco, CA 94080.
  • Snipas SJ; National Cancer Institute-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
  • Salvesen GS; National Cancer Institute-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
  • Lai P; Early Clinical Development OMNI Department, Genentech, Inc., South San Francisco, CA 94080.
  • Honigberg L; OMNI Biomarker Development, Genentech, Inc., South San Francisco, CA 94080.
  • van Lookeren Campagne M; Inflammation & Oncology Research, Amgen, South San Francisco, CA 94080.
  • Kirchhofer D; Department of Early Discovery Biochemistry, Genentech, Inc., South San Francisco, CA 94080.
  • Baruch A; Biomarker Development, Calico Life Sciences, LLC, South San Francisco, CA 94080 barucha@calicolabs.com lill.jennie@gene.com.
  • Lill JR; Department of Microchemistry, Proteomics & Lipidomics, Genentech, Inc., South San Francisco, CA 94080; barucha@calicolabs.com lill.jennie@gene.com.
Proc Natl Acad Sci U S A ; 117(18): 9952-9963, 2020 05 05.
Article en En | MEDLINE | ID: mdl-32345717
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Anticuerpos Antiidiotipos / Proteínas Adaptadoras Transductoras de Señales / Atrofia Geográfica / Serina Peptidasa A1 que Requiere Temperaturas Altas / Degeneración Macular Tipo de estudio: Diagnostic_studies Límite: Aged / Animals / Female / Humans / Male Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2020 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Anticuerpos Antiidiotipos / Proteínas Adaptadoras Transductoras de Señales / Atrofia Geográfica / Serina Peptidasa A1 que Requiere Temperaturas Altas / Degeneración Macular Tipo de estudio: Diagnostic_studies Límite: Aged / Animals / Female / Humans / Male Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2020 Tipo del documento: Article