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A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway.
Ghergurovich, Jonathan M; García-Cañaveras, Juan C; Wang, Joshua; Schmidt, Emily; Zhang, Zhaoyue; TeSlaa, Tara; Patel, Harshel; Chen, Li; Britt, Emily C; Piqueras-Nebot, Marta; Gomez-Cabrera, Mari Carmen; Lahoz, Agustín; Fan, Jing; Beier, Ulf H; Kim, Hahn; Rabinowitz, Joshua D.
Afiliación
  • Ghergurovich JM; Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
  • García-Cañaveras JC; Department of Molecular Biology, Princeton University, Princeton, NJ, USA.
  • Wang J; Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
  • Schmidt E; Department of Chemistry, Princeton University, Princeton, NJ, USA.
  • Zhang Z; Department of Chemistry, Princeton University, Princeton, NJ, USA.
  • TeSlaa T; Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
  • Patel H; Department of Chemistry, Princeton University, Princeton, NJ, USA.
  • Chen L; Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
  • Britt EC; Department of Chemistry, Princeton University, Princeton, NJ, USA.
  • Piqueras-Nebot M; Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
  • Gomez-Cabrera MC; Department of Chemistry, Princeton University, Princeton, NJ, USA.
  • Lahoz A; Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
  • Fan J; Department of Chemistry, Princeton University, Princeton, NJ, USA.
  • Beier UH; Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
  • Kim H; Department of Chemistry, Princeton University, Princeton, NJ, USA.
  • Rabinowitz JD; Morgridge Institute for Research, Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Nat Chem Biol ; 16(7): 731-739, 2020 07.
Article en En | MEDLINE | ID: mdl-32393898
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Vía de Pentosa Fosfato / Linfocitos / Inhibidores Enzimáticos / Glucosafosfato Deshidrogenasa / Macrófagos / Neutrófilos Límite: Animals / Humans Idioma: En Revista: Nat Chem Biol Asunto de la revista: BIOLOGIA / QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Vía de Pentosa Fosfato / Linfocitos / Inhibidores Enzimáticos / Glucosafosfato Deshidrogenasa / Macrófagos / Neutrófilos Límite: Animals / Humans Idioma: En Revista: Nat Chem Biol Asunto de la revista: BIOLOGIA / QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos