Effects of STAT3 polymorphisms and pharmacokinetics on the clinical outcomes of gefitinib treatment in patients with EGFR-mutation positive non-small cell lung cancer.

Yokota, Hayato; Sato, Kazuhiro; Sakamoto, Sho; Okuda, Yuji; Asano, Mariko; Takeda, Masahide; Nakayama, Katsutoshi; Miura, Masatomo

Yokota, Hayato; Sato, Kazuhiro; Sakamoto, Sho; Okuda, Yuji; Asano, Mariko; Takeda, Masahide; Nakayama, Katsutoshi; Miura, Masatomo.

Afiliación

Yokota H; Department of Pharmacy, Akita University Hospital, Akita, Japan.
Sato K; Division of Respiratory Medicine, Department of Internal Medicine, Akita University School of Medicine, Akita, Japan.
Sakamoto S; Division of Respiratory Medicine, Department of Internal Medicine, Akita University School of Medicine, Akita, Japan.
Okuda Y; Division of Respiratory Medicine, Department of Internal Medicine, Akita University School of Medicine, Akita, Japan.
Asano M; Division of Respiratory Medicine, Department of Internal Medicine, Akita University School of Medicine, Akita, Japan.
Takeda M; Division of Respiratory Medicine, Department of Internal Medicine, Akita University School of Medicine, Akita, Japan.
Nakayama K; Division of Respiratory Medicine, Department of Internal Medicine, Akita University School of Medicine, Akita, Japan.
Miura M; Department of Pharmacy, Akita University Hospital, Akita, Japan.

J Clin Pharm Ther ; 45(4): 652-659, 2020 Aug.

Article en En | MEDLINE | ID: mdl-32402096

Asunto(s)

Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico; Carcinoma de Pulmón de Células no Pequeñas/genética; Gefitinib/uso terapéutico; Neoplasias Pulmonares/tratamiento farmacológico; Neoplasias Pulmonares/genética; Factor de Transcripción STAT3/genética; Anciano; Alelos; Antineoplásicos/uso terapéutico; Supervivencia sin Enfermedad; Receptores ErbB/genética; Femenino; Humanos; Masculino; Persona de Mediana Edad; Mutación/genética; Polimorfismo Genético/genética; Inhibidores de Proteínas Quinasas/uso terapéutico

Palabras clave

gefitinib; plasma concentration; polymorphism; signal transducer and activator of transcription 3

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / Factor de Transcripción STAT3 / Gefitinib / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Pharm Ther Asunto de la revista: FARMACIA / TERAPEUTICA Año: 2020 Tipo del documento: Article País de afiliación: Japón

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