The ThiL enzyme is a valid antibacterial target essential for both thiamine biosynthesis and salvage pathways in <i>Pseudomonas aeruginosa</i>.

Kim, Hyung Jun; Lee, Hyunjung; Lee, Yunmi; Choi, Inhee; Ko, Yoonae; Lee, Sangchul; Jang, Soojin

The ThiL enzyme is a valid antibacterial target essential for both thiamine biosynthesis and salvage pathways in Pseudomonas aeruginosa.

Kim, Hyung Jun; Lee, Hyunjung; Lee, Yunmi; Choi, Inhee; Ko, Yoonae; Lee, Sangchul; Jang, Soojin.

Afiliación

Kim HJ; Discovery Biology Department, Antibacterial Resistance Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do, Republic of Korea.
Lee H; Discovery Biology Department, Antibacterial Resistance Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do, Republic of Korea.
Lee Y; Discovery Biology Department, Antibacterial Resistance Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do, Republic of Korea.
Choi I; Translation Research Department, Medicinal Chemistry, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do, Republic of Korea.
Ko Y; Translation Research Department, Medicinal Chemistry, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do, Republic of Korea.
Lee S; Translation Research Department, Medicinal Chemistry, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do, Republic of Korea.
Jang S; Discovery Biology Department, Antibacterial Resistance Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do, Republic of Korea soojin.jang@ip-korea.org.

J Biol Chem ; 295(29): 10081-10091, 2020 07 17.

Article en En | MEDLINE | ID: mdl-32404369

Asunto(s)

Antibacterianos/farmacología; Proteínas Bacterianas; Inhibidores Enzimáticos/farmacología; Fosfotransferasas (Aceptor del Grupo Fosfato); Pseudomonas aeruginosa/enzimología; Tiamina/biosíntesis; Proteínas Bacterianas/antagonistas & inhibidores; Proteínas Bacterianas/genética; Proteínas Bacterianas/metabolismo; Fosfotransferasas (Aceptor del Grupo Fosfato)/antagonistas & inhibidores; Fosfotransferasas (Aceptor del Grupo Fosfato)/genética; Fosfotransferasas (Aceptor del Grupo Fosfato)/metabolismo; Pseudomonas aeruginosa/genética

Palabras clave

PaThiL; Pseudomonas aeruginosa; antibacterial target; bacterial metabolism; bacterial pathogenesis; drug target; infection; thiamine; thiamine monophosphate kinase; virulence

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pseudomonas aeruginosa / Tiamina / Proteínas Bacterianas / Fosfotransferasas (Aceptor del Grupo Fosfato) / Inhibidores Enzimáticos / Antibacterianos Idioma: En Revista: J Biol Chem Año: 2020 Tipo del documento: Article

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