Engineered anti-inflammatory peptides inspired by mapping an evasin-chemokine interaction.

Darlot, Benoit; Eaton, James R O; Geis-Asteggiante, Lucia; Yakala, Gopala K; Karuppanan, Kalimuthu; Davies, Graham; Robinson, Carol V; Kawamura, Akane; Bhattacharya, Shoumo

Darlot, Benoit; Eaton, James R O; Geis-Asteggiante, Lucia; Yakala, Gopala K; Karuppanan, Kalimuthu; Davies, Graham; Robinson, Carol V; Kawamura, Akane; Bhattacharya, Shoumo.

Afiliación

Darlot B; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom.
Eaton JRO; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom.
Geis-Asteggiante L; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Yakala GK; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom.
Karuppanan K; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Davies G; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Robinson CV; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Kawamura A; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom.
Bhattacharya S; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom akane.kawamura@ncl.ac.uk sbhattac@well.ox.ac.uk.

J Biol Chem ; 295(32): 10926-10939, 2020 08 07.

Article en En | MEDLINE | ID: mdl-32471866

Asunto(s)

Antiinflamatorios/química; Quimiocina CCL8/metabolismo; Péptidos/química; Ingeniería de Proteínas; Receptores de Quimiocina/metabolismo; Secuencia de Aminoácidos; Animales; Antiinflamatorios/farmacología; Dimerización; Humanos; Espectrometría de Masas/métodos; Péptidos/farmacología; Unión Proteica; Homología de Secuencia de Aminoácido; Garrapatas/metabolismo

Palabras clave

CC motif chemokine ligand (CCL); chemokine; chemotaxis; evasin; hostpathogen interaction; hydrogen exchange mass spectrometry; immune response; inflammation; innate immunity; mass spectrometry; peptide interaction; peptides; protein structure; proteinprotein interaction; tick

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Péptidos / Ingeniería de Proteínas / Receptores de Quimiocina / Quimiocina CCL8 / Antiinflamatorios Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Biol Chem Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido

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