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Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer.
Simões, Bruno M; Santiago-Gómez, Angélica; Chiodo, Chiara; Moreira, Tiago; Conole, Daniel; Lovell, Scott; Alferez, Denis; Eyre, Rachel; Spence, Katherine; Sarmiento-Castro, Aida; Kohler, Bertram; Morisset, Ludivine; Lanzino, Marilena; Andò, Sebastiano; Marangoni, Elisabetta; Sims, Andrew H; Tate, Edward W; Howell, Sacha J; Clarke, Robert B.
Afiliación
  • Simões BM; Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. bruno.simoes@manchester.ac.uk.
  • Santiago-Gómez A; Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
  • Chiodo C; Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
  • Moreira T; Department of Pharmacy, University of Calabria, Arcavacata di Rende, Italy.
  • Conole D; Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
  • Lovell S; Molecular Sciences Research Hub, Imperial College, London, UK.
  • Alferez D; Molecular Sciences Research Hub, Imperial College, London, UK.
  • Eyre R; Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
  • Spence K; Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
  • Sarmiento-Castro A; Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
  • Kohler B; Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
  • Morisset L; Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
  • Lanzino M; Institut Curie, PSL Research University, Translational Research Department, Paris, France.
  • Andò S; Department of Pharmacy, University of Calabria, Arcavacata di Rende, Italy.
  • Marangoni E; Department of Pharmacy, University of Calabria, Arcavacata di Rende, Italy.
  • Sims AH; Institut Curie, PSL Research University, Translational Research Department, Paris, France.
  • Tate EW; Applied Bioinformatics of Cancer Group, University of Edinburgh Cancer Research UK Centre, Edinburgh, UK.
  • Howell SJ; Molecular Sciences Research Hub, Imperial College, London, UK.
  • Clarke RB; Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. sacha.howell@christie.nhs.uk.
Oncogene ; 39(25): 4896-4908, 2020 06.
Article en En | MEDLINE | ID: mdl-32472077
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Células Madre Neoplásicas / Neoplasias de la Mama / Transducción de Señal / Receptores de Estrógenos / Isotiocianatos / Factor de Transcripción STAT3 Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Oncogene Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Células Madre Neoplásicas / Neoplasias de la Mama / Transducción de Señal / Receptores de Estrógenos / Isotiocianatos / Factor de Transcripción STAT3 Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Oncogene Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido