Kidney Infarction in Patients With COVID-19.
Am J Kidney Dis
; 76(3): 431-435, 2020 09.
Article
en En
| MEDLINE
| ID: mdl-32479921
ABSTRACT
Coronavirus disease 2019 (COVID-19) is a contagious life-threatening infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Recent findings indicate an increased risk for acute kidney injury during COVID-19 infection. The pathophysiologic mechanisms leading to acute kidney injury in COVID-19 infection are unclear but may include direct cytopathic effects of the virus on kidney tubular and endothelial cells, indirect damage caused by virus-induced cytokine release, and kidney hypoperfusion due to a restrictive fluid strategy. In this report of 2 cases, we propose an additional pathophysiologic mechanism. We describe 2 cases in which patients with COVID-19 infection developed a decrease in kidney function due to kidney infarction. These patients did not have atrial fibrillation. One of these patients was treated with therapeutic doses of low-molecular-weight heparin, after which no further deterioration in kidney function was observed. Our findings implicate that the differential diagnosis of acute kidney injury in COVID-19-infected patients should include kidney infarction, which may have important preventive and therapeutic implications.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neumonía Viral
/
Infecciones por Coronavirus
/
Lesión Renal Aguda
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Betacoronavirus
/
Infarto
/
Riñón
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
Límite:
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Am J Kidney Dis
Año:
2020
Tipo del documento:
Article