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A head-to-head comparison between two commercial software packages for hybrid dosimetry after peptide receptor radionuclide therapy.
Huizing, Daphne M V; Peters, Steffie M B; Versleijen, Michelle W J; Martens, Esther; Verheij, Marcel; Sinaasappel, Michiel; Stokkel, Marcel P M; de Wit-van der Veen, Berlinda J.
Afiliación
  • Huizing DMV; Department of Nuclear Medicine, Netherlands Cancer Institute, Plesmanlaan 121, 1066, CX, Amsterdam, The Netherlands. d.huizing@nki.nl.
  • Peters SMB; Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Versleijen MWJ; Department of Nuclear Medicine, Netherlands Cancer Institute, Plesmanlaan 121, 1066, CX, Amsterdam, The Netherlands.
  • Martens E; Department of Clinical Physics and Instrumentation, Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • Verheij M; Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Sinaasappel M; Department of Clinical Physics and Instrumentation, Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • Stokkel MPM; Department of Nuclear Medicine, Netherlands Cancer Institute, Plesmanlaan 121, 1066, CX, Amsterdam, The Netherlands.
  • de Wit-van der Veen BJ; Department of Nuclear Medicine, Netherlands Cancer Institute, Plesmanlaan 121, 1066, CX, Amsterdam, The Netherlands. l.vd.veen@nki.nl.
EJNMMI Phys ; 7(1): 36, 2020 Jun 01.
Article en En | MEDLINE | ID: mdl-32488632
BACKGROUND: Dosimetry after peptide receptor radionuclide therapy (PRRT) is increasing; however, comparing or pooling of dosimetric results can be challenging since different approaches are used. The aim of this study was to perform a head-to-head comparison of post-PRRT curve fitting and dosimetry obtained from two commercial software Hybrid Viewer Dosimetry and PLANET Dose. METHODS: Post-therapy imaging included planar scintigraphy at 0.5, 4, 24 and 72 h post-injection of [177Lu]Lu-DOTA-TATE for kinetics and SPECT/CT at 24 h for quantification. On planar imaging, 2 cm regions-of-interest were positioned within the inferior pole of the kidneys and kidney cortex was segmented on low-dose CT. On both planar and SPECT/CT, 2 cm spheres were positioned in the proximal humerus (red marrow equivalent) and in the region with the highest uptake in tumour lesions. TACs were estimated with mono- and bi-exponential fits in both software systems, after which tissue absorbed (kidney, red marrow, tumour) and biological effective doses (kidney) were calculated. Agreement-ICC, Spearman correlation and Bland-Altman plots were used to compare results. RESULTS: Mono-exponential fits showed the most comparable correlation between the measured and fitted data between both software. The ICC between absorbed dose outcomes was > 0.7 in tumour lesions and kidneys, but negative for the red marrow. Spearman correlation was > 0.9 for mono-exponential fits in kidneys and tumour lesions, and -0.7 in red marrow. Bi-exponential fits resulted in lower correlations and agreement values. Concordance between both software packages concerning the number of PRRT cycles with 7.4 GBq was observed based on a biological effective dose limit of 27 Gy to the kidneys. CONCLUSION: [177Lu]Lu-DOTA-TATE dosimetry results of two software packages were comparable in the same dataset, despite the limited number of imaging time-points. However, these results should be verified in a larger cohort before pooling of clinical data, as the obtained results will depend on acquisition protocol, timing and lesions definition.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Guideline Idioma: En Revista: EJNMMI Phys Año: 2020 Tipo del documento: Article País de afiliación: Países Bajos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Guideline Idioma: En Revista: EJNMMI Phys Año: 2020 Tipo del documento: Article País de afiliación: Países Bajos