Oral intake of lipopolysaccharide regulates toll-like receptor 4-dependent granulopoiesis.
Exp Biol Med (Maywood)
; 245(14): 1254-1259, 2020 08.
Article
en En
| MEDLINE
| ID: mdl-32515223
ABSTRACT
IMPACT STATEMENT In our present study, we investigated the impact of LPS on neutrophil homeostasis and found that oral intake is sufficient to induce hematopoietic stem and progenitor cell fate decisions towards the neutrophil lineage independent of G-CSF. In addition, TLR4 has been identified as the indispensable sensor for oral LPS-modulated steady-state granulopoiesis. We provide evidence that the gastrointestinal microbiome is critical for neutrophil homeostasis, which has implications for patients being treated with chemotherapy or antimicrobial therapy, since both are significantly influencing the composition of the intestinal microbiome.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Lipopolisacáridos
/
Receptor Toll-Like 4
/
Granulocitos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Exp Biol Med (Maywood)
Asunto de la revista:
BIOLOGIA
/
FISIOLOGIA
/
MEDICINA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Alemania