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Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease.
Álvarez-Quilón, Alejandro; Wojtaszek, Jessica L; Mathieu, Marie-Claude; Patel, Tejas; Appel, C Denise; Hustedt, Nicole; Rossi, Silvia Emma; Wallace, Bret D; Setiaputra, Dheva; Adam, Salomé; Ohashi, Yota; Melo, Henrique; Cho, Tiffany; Gervais, Christian; Muñoz, Ivan M; Grazzini, Eric; Young, Jordan T F; Rouse, John; Zinda, Michael; Williams, R Scott; Durocher, Daniel.
Afiliación
  • Álvarez-Quilón A; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada.
  • Wojtaszek JL; Structural Cell Biology Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA.
  • Mathieu MC; Repare Therapeutics, 7210 Frederick-Banting, Suite 100, St-Laurent, QC H4S 2A1, Canada.
  • Patel T; Structural Cell Biology Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA.
  • Appel CD; Structural Cell Biology Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA.
  • Hustedt N; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada.
  • Rossi SE; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada.
  • Wallace BD; Structural Cell Biology Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA.
  • Setiaputra D; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada.
  • Adam S; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada.
  • Ohashi Y; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada.
  • Melo H; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada.
  • Cho T; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.
  • Gervais C; National Research Council Canada Human Health Therapeutics Research Center, 6100 Royalmount Avenue, Montreal, QC H4P 2R2, Canada.
  • Muñoz IM; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
  • Grazzini E; National Research Council Canada Human Health Therapeutics Research Center, 6100 Royalmount Avenue, Montreal, QC H4P 2R2, Canada.
  • Young JTF; Repare Therapeutics, 7210 Frederick-Banting, Suite 100, St-Laurent, QC H4S 2A1, Canada.
  • Rouse J; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
  • Zinda M; Repare Therapeutics, 7210 Frederick-Banting, Suite 100, St-Laurent, QC H4S 2A1, Canada.
  • Williams RS; Structural Cell Biology Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA. Electronic address: willia
  • Durocher D; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada. Electronic address: durocher@lunenfeld.ca.
Mol Cell ; 78(6): 1152-1165.e8, 2020 06 18.
Article en En | MEDLINE | ID: mdl-32516598
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteína BRCA1 / Proteína BRCA2 / ADN-(Sitio Apurínico o Apirimidínico) Liasa / Endonucleasas / Enzimas Multifuncionales Límite: Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2020 Tipo del documento: Article País de afiliación: Canadá
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteína BRCA1 / Proteína BRCA2 / ADN-(Sitio Apurínico o Apirimidínico) Liasa / Endonucleasas / Enzimas Multifuncionales Límite: Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2020 Tipo del documento: Article País de afiliación: Canadá