A conserved evolutionary mechanism permits &#916;9 desaturation of very-long-chain fatty acyl lipids.

Cai, Yuanheng; Yu, Xiao-Hong; Chai, Jin; Liu, Chang-Jun; Shanklin, John

A conserved evolutionary mechanism permits Δ9 desaturation of very-long-chain fatty acyl lipids.

Cai, Yuanheng; Yu, Xiao-Hong; Chai, Jin; Liu, Chang-Jun; Shanklin, John.

Afiliación

Cai Y; Biochemistry & Cell Biology Department, Stony Brook University, Stony Brook, New York, USA.
Yu XH; Biochemistry & Cell Biology Department, Stony Brook University, Stony Brook, New York, USA.
Chai J; Biology Department, Brookhaven National Laboratory, Upton, New York, USA.
Liu CJ; Biology Department, Brookhaven National Laboratory, Upton, New York, USA.
Shanklin J; Biochemistry & Cell Biology Department, Stony Brook University, Stony Brook, New York, USA shanklin@bnl.gov.

J Biol Chem ; 295(32): 11337-11345, 2020 08 07.

Article en En | MEDLINE | ID: mdl-32527722

Asunto(s)

Evolución Biológica; Ácido Graso Desaturasas/metabolismo; Metabolismo de los Lípidos; Sustitución de Aminoácidos; Ácido Graso Desaturasas/química; Ácido Graso Desaturasas/genética; Mutación; Especificidad por Sustrato

Palabras clave

chain length specificity; desaturase; enzyme; enzyme mutation; fatty acid metabolism; metalloenzyme; monoene; phospholipid; stearoyl-CoA desaturase; structural determinants; substrate specificity; very-long-chain fatty acid; Δ9 integral membrane desaturase

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Metabolismo de los Lípidos / Evolución Biológica / Ácido Graso Desaturasas Idioma: En Revista: J Biol Chem Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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