Pharmacological clearance of misfolded rhodopsin for the treatment of RHO-associated retinitis pigmentosa.

Liu, Xujie; Feng, Bing; Vats, Abhishek; Tang, Hong; Seibel, William; Swaroop, Manju; Tawa, Gregory; Zheng, Wei; Byrne, Leah; Schurdak, Mark; Chen, Yuanyuan

Liu, Xujie; Feng, Bing; Vats, Abhishek; Tang, Hong; Seibel, William; Swaroop, Manju; Tawa, Gregory; Zheng, Wei; Byrne, Leah; Schurdak, Mark; Chen, Yuanyuan.

Afiliación

Liu X; Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, USA.
Feng B; McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Vats A; Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, USA.
Tang H; McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Seibel W; Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, USA.
Swaroop M; McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Tawa G; Drug Discovery Center, University of Cincinnati, Cincinnati, OH, USA.
Zheng W; Drug Discovery Center, University of Cincinnati, Cincinnati, OH, USA.
Byrne L; Oncology Department, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Schurdak M; National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.
Chen Y; National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.

FASEB J ; 34(8): 10146-10167, 2020 08.

Article en En | MEDLINE | ID: mdl-32536017

Asunto(s)

Retinitis Pigmentosa/metabolismo; Rodopsina/metabolismo; Animales; Línea Celular; Electrorretinografía/métodos; Femenino; Células HEK293; Humanos; Masculino; Ratones; Proteínas Mutantes/metabolismo; Mutación/genética; Células 3T3 NIH; Células Fotorreceptoras/metabolismo; Complejo de la Endopetidasa Proteasomal/metabolismo; Pliegue de Proteína; Retina/metabolismo; Retinitis Pigmentosa/genética; Rodopsina/genética

Palabras clave

high-throughput screening; methotrexate; misfolded protein degradation

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Rodopsina / Retinitis Pigmentosa Tipo de estudio: Risk_factors_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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