Reproductive period and dementia: A 44-year longitudinal population study of Swedish women.
Alzheimers Dement
; 16(8): 1153-1163, 2020 08.
Article
en En
| MEDLINE
| ID: mdl-32573980
ABSTRACT
INTRODUCTION:
Longitudinal studies examining the effect of endogenous estrogens on dementia risk are needed to understand why women have higher dementia incidence than men after age 85.METHODS:
A population-based sample of women with natural menopause (N = 1364) from Gothenburg, Sweden, was followed from 1968-2012. Information on endogenous estrogens (age at menarche and menopause, number of pregnancies, and months of breastfeeding) was obtained from interviews in 1968-1992. Dementia was diagnosed according to established criteria based on information from neuropsychiatric examinations and close informant interviews.RESULTS:
We found that longer reproductive period was associated with increased risk of dementia (hazard ratio [HR] per year 1.06, 95% confidence interval [CI] 1.03-1.20) and Alzheimer's disease (AD) (1.06, 1.02-1.11), particularly for those with dementia (1.10, 1.04-1.17) and AD (1.15, 1.06-1.26) onset after age 85.DISCUSSION:
These results may explain why women have higher dementia incidence compared to men after age 85, the age with the highest number of dementia cases.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Reproducción
/
Demencia
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
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Aged80
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Female
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Humans
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Middle aged
/
Pregnancy
País/Región como asunto:
Europa
Idioma:
En
Revista:
Alzheimers Dement
Año:
2020
Tipo del documento:
Article
País de afiliación:
Suecia