The association between adiponectin gene rs182052 polymorphism and cancer risk: a meta-analysis.
Biosci Rep
; 40(6)2020 06 26.
Article
en En
| MEDLINE
| ID: mdl-32588903
ABSTRACT
BACKGROUND:
The evidence for an association between the adiponectin gene (ADIPOQ) polymorphism rs182052 and cancer risk is inconsistent. We performed a meta-analysis to obtain more precise conclusions.METHODS:
The PubMed, Embase, and Web of Science databases were searched until July 11, 2019. And seven epidemiology studies were retrieved, including 4,929 cases and 5,625 controls. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were calculated to evaluate the strength of the association.RESULTS:
The meta-analysis demonstrated that rs182052 significantly increased the risk of cancer under the allele, homozygote, dominant, and recessive models, based on an overall analysis (A vs. G OR, 1.09, 95% CI, 1.03-1.15, P=0.003; AA vs. GG OR, 1.20, 95% CI, 1.07-1.34, P=0.002; AA+GA vs. GG OR, 1.12, 95% CI, 1.03-1.22, P=0.010; AA vs. GA+GG OR, 1.12, 95% CI, 1.01-1.23, P=0.025). In the stratified analysis by ethnicity, rs182052 significantly increased the cancer risk in both Asian and Caucasian populations under one or several genetic models. In the stratified analysis by cancer type, rs182052 significantly increased the risk of renal cell carcinoma (RCC) under the five models.CONCLUSIONS:
Meta-analysis based on present studies suggests that rs182052 can increase the cancer risk.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Polimorfismo de Nucleótido Simple
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Adiponectina
/
Neoplasias
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
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Observational_studies
/
Prognostic_studies
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Risk_factors_studies
/
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Biosci Rep
Año:
2020
Tipo del documento:
Article
País de afiliación:
China