A Roadblock-and-Kill Mechanism of Action Model for the DNA-Targeting Antibiotic Ciprofloxacin.

Ojkic, Nikola; Lilja, Elin; Direito, Susana; Dawson, Angela; Allen, Rosalind J; Waclaw, Bartlomiej

Ojkic, Nikola; Lilja, Elin; Direito, Susana; Dawson, Angela; Allen, Rosalind J; Waclaw, Bartlomiej.

Afiliación

Ojkic N; SUPA, School of Physics and Astronomy, University of Edinburgh, Edinburgh, United Kingdom.
Lilja E; SUPA, School of Physics and Astronomy, University of Edinburgh, Edinburgh, United Kingdom.
Direito S; SUPA, School of Physics and Astronomy, University of Edinburgh, Edinburgh, United Kingdom.
Dawson A; SUPA, School of Physics and Astronomy, University of Edinburgh, Edinburgh, United Kingdom.
Allen RJ; SUPA, School of Physics and Astronomy, University of Edinburgh, Edinburgh, United Kingdom.
Waclaw B; Centre for Synthetic and Systems Biology, Edinburgh, United Kingdom.

Antimicrob Agents Chemother ; 64(9)2020 08 20.

Article en En | MEDLINE | ID: mdl-32601161

Asunto(s)

Antibacterianos; Ciprofloxacina; Antibacterianos/farmacología; Ciprofloxacina/farmacología; ADN; Girasa de ADN/genética; Topoisomerasa de ADN IV/genética; ADN-Topoisomerasas de Tipo II/genética; ADN Bacteriano/genética; Escherichia coli/genética; Fluoroquinolonas; Mutación

Palabras clave

antibiotics; computer modeling; fluoroquinolones; mechanisms of action

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ciprofloxacina / Antibacterianos Tipo de estudio: Prognostic_studies Idioma: En Revista: Antimicrob Agents Chemother Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido

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