Synthesis and antitumor activity of &#945;,ß-unsaturated carbonyl moiety- containing oleanolic acid derivatives targeting PI3K/AKT/mTOR signaling pathway.

Wang, Shi-Sheng; Zhang, Qiao-Li; Chu, Peng; Kong, Ling-Qi; Li, Guang-Zhe; Li, Yue-Qing; Yang, Li; Zhao, Wei-Jie; Guo, Xiu-Han; Tang, Ze-Yao

Synthesis and antitumor activity of α,ß-unsaturated carbonyl moiety- containing oleanolic acid derivatives targeting PI3K/AKT/mTOR signaling pathway.

Wang, Shi-Sheng; Zhang, Qiao-Li; Chu, Peng; Kong, Ling-Qi; Li, Guang-Zhe; Li, Yue-Qing; Yang, Li; Zhao, Wei-Jie; Guo, Xiu-Han; Tang, Ze-Yao.

Afiliación

Wang SS; Department of Pharmacy, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China.
Zhang QL; Department of Pharmacy, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China.
Chu P; Department of Pharmacology, Dalian Medical University, Dalian 116044, China.
Kong LQ; Department of Pharmacy, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China.
Li GZ; Department of Pharmacy, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China.
Li YQ; Department of Pharmacy, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China.
Yang L; Department of Pharmacy, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China.
Zhao WJ; Department of Pharmacy, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China.
Guo XH; Department of Pharmacy, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China. Electronic address: kakumicin@dlut.edu.cn.
Tang ZY; Department of Pharmacology, Dalian Medical University, Dalian 116044, China. Electronic address: tangzeyao411@dmu.edu.cn.

Bioorg Chem ; 101: 104036, 2020 08.

Article en En | MEDLINE | ID: mdl-32629283

Asunto(s)

Antineoplásicos/uso terapéutico; Ácido Oleanólico/uso terapéutico; Fosfatidilinositol 3-Quinasas/efectos de los fármacos; Proteínas Proto-Oncogénicas c-akt/efectos de los fármacos; Antineoplásicos/farmacología; Humanos; Estructura Molecular; Ácido Oleanólico/farmacología; Transducción de Señal; Relación Estructura-Actividad

Palabras clave

Anticancer; Cell apoptosis induction; Oleanolic acid derivatives; PI3K/AKT/mTOR signaling pathway; S phase arrest

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ácido Oleanólico / Fosfatidilinositol 3-Quinasas / Proteínas Proto-Oncogénicas c-akt / Antineoplásicos Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2020 Tipo del documento: Article País de afiliación: China

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google