AL 721: a potent membrane modulating agent of human T-lymphocytes?
Wien Klin Wochenschr
; 100(17): 597-9, 1988 Sep 09.
Article
en En
| MEDLINE
| ID: mdl-3263733
ABSTRACT
This report deals with AL 721, a reputedly potent membrane fluidizing agent. A correlation has been sought between the effects of AL 721 on membrane fluidity and mitogen responsiveness of human peripheral blood lymphocytes. The AL 721-induced increase in membrane "fluidity", as measured by fluorescence polarisation with 1,6-diphenyl-1,3,5-hexatriene, was found to be an artefact arising from lipid uptake by monocytes. Mitogen responses were enhanced by inclusion of AL 721 in the serum-free culture medium. However, this observation is more likely explained by provision of lymphocytes with nutritional lipids required for optimal growth in vitro, than altered responsiveness of "fluidized" lymphocytes.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fosfatidilcolinas
/
Fosfatidiletanolaminas
/
Activación de Linfocitos
/
Linfocitos T
/
Glicéridos
/
Fluidez de la Membrana
Límite:
Adolescent
/
Adult
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Aged
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Humans
/
Middle aged
Idioma:
En
Revista:
Wien Klin Wochenschr
Año:
1988
Tipo del documento:
Article