Patterns of farm exposure are associated with reduced incidence of atopic dermatitis in early life.
J Allergy Clin Immunol
; 146(6): 1379-1386.e6, 2020 12.
Article
en En
| MEDLINE
| ID: mdl-32650021
ABSTRACT
BACKGROUND:
Farm exposures may reduce the risk of atopic dermatitis (AD) in children, but this is controversial and US data are limited.OBJECTIVE:
This study was conducted to identify patterns of farm exposure in Wisconsin family farms that modify AD incidence and prevalence in early childhood.METHODS:
Environmental exposures, health history, and clinical outcomes were prospectively recorded for 111 farm families and 129 non-farm families enrolled in the Wisconsin Infant Study Cohort birth cohort study. Exposures from the prenatal and early postnatal (2-month) visits were evaluated together with parental report of AD diagnosis by a health care provider through age 24 months. Latent class analysis was performed with prenatal and early postnatal farm-exposure variables to assign farm children to 3 classes.RESULTS:
Overall, children of farm families had reduced AD incidence (P = .03). Within farm families, exposures including poultry (3% vs 28%; P = .003), pig (4% vs 25%; P = .04), feed grain (13% vs 34%; P = .02), and number of animal species were inversely associated with AD incidence. Among the latent class groups, children in families with diverse or more intense farm exposures (classes A and B) had reduced AD incidence, whereas low-exposure (class C) infants had AD incidence similar to that in nonfarm children.CONCLUSIONS:
Infants in Wisconsin farm families had reduced AD incidence, and patterns of farm exposures further defined AD risk. These findings suggest that exposure to diverse farm animals, feed, and bedding during the prenatal period and in early infancy reduce the risk of early-onset AD, a phenotype associated with multiple other atopic diseases.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Efectos Tardíos de la Exposición Prenatal
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Población Rural
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Exposición Profesional
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Exposición Materna
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Agricultura
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Dermatitis Atópica
Tipo de estudio:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Infant
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Male
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Middle aged
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Newborn
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Pregnancy
País/Región como asunto:
America do norte
Idioma:
En
Revista:
J Allergy Clin Immunol
Año:
2020
Tipo del documento:
Article