From Input to Output: The Lap/c-di-GMP Biofilm Regulatory Circuit.
Annu Rev Microbiol
; 74: 607-631, 2020 09 08.
Article
en En
| MEDLINE
| ID: mdl-32689917
ABSTRACT
Biofilms are the dominant bacterial lifestyle. The regulation of the formation and dispersal of bacterial biofilms has been the subject of study in many organisms. Over the last two decades, the mechanisms of Pseudomonas fluorescens biofilm formation and regulation have emerged as among the best understood of any bacterial biofilm system. Biofilm formation by P. fluorescens occurs through the localization of an adhesin, LapA, to the outer membrane via a variant of the classical type I secretion system. The decision between biofilm formation and dispersal is mediated by LapD, a c-di-GMP receptor, and LapG, a periplasmic protease, which together control whether LapA is retained or released from the cell surface. LapA localization is also controlled by a complex network of c-di-GMP-metabolizing enzymes. This review describes the current understanding of LapA-mediated biofilm formation by P. fluorescens and discusses several emerging models for the regulation and function of this adhesin.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas Bacterianas
/
Pseudomonas fluorescens
/
Regulación Bacteriana de la Expresión Génica
/
GMP Cíclico
/
Biopelículas
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Annu Rev Microbiol
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos