Impact of intrauterine hypoxia on adolescent and adult cognitive function in rat offspring: sexual differences and the effects of spermidine intervention.

Mao, Meng; Yang, Lin; Jin, Zhuo; Li, Ling-Xu; Wang, Yan-Ru; Li, Ting-Ting; Zhao, Ya-Jun; Ai, Jing

Mao, Meng; Yang, Lin; Jin, Zhuo; Li, Ling-Xu; Wang, Yan-Ru; Li, Ting-Ting; Zhao, Ya-Jun; Ai, Jing.

Afiliación

Mao M; Department of Pharmacology, College of Pharmacy of Harbin Medical University (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin, 150086, China.
Yang L; Department of Pharmacology, College of Pharmacy of Harbin Medical University (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin, 150086, China.
Jin Z; Department of Pharmacology, College of Pharmacy of Harbin Medical University (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin, 150086, China.
Li LX; Department of Pathophysiology, Harbin Medical University, Harbin, 150086, China.
Wang YR; Department of Pharmacology, College of Pharmacy of Harbin Medical University (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin, 150086, China.
Li TT; Department of Pharmacology, College of Pharmacy of Harbin Medical University (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin, 150086, China.
Zhao YJ; Department of Pathophysiology, Harbin Medical University, Harbin, 150086, China. zhaoyajun1964@163.com.
Ai J; Department of Pharmacology, College of Pharmacy of Harbin Medical University (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin, 150086, China. azhrbmu@126.com.

Acta Pharmacol Sin ; 42(3): 361-369, 2021 Mar.

Article en En | MEDLINE | ID: mdl-32694754

Asunto(s)

Cognición/fisiología; Disfunción Cognitiva/tratamiento farmacológico; Hipoxia/fisiopatología; Espermidina/uso terapéutico; Útero/fisiopatología; Secretasas de la Proteína Precursora del Amiloide/metabolismo; Precursor de Proteína beta-Amiloide/metabolismo; Animales; Ácido Aspártico Endopeptidasas/metabolismo; Reacción de Prevención/efectos de los fármacos; Reacción de Prevención/fisiología; Peso Corporal/efectos de los fármacos; Peso Corporal/fisiología; Cognición/efectos de los fármacos; Disfunción Cognitiva/etiología; Femenino; Hipoxia/complicaciones; Masculino; Embarazo; Ratas Wistar; Factores Sexuales; Proteínas tau/metabolismo

Palabras clave

cognitive defects; intrauterine hypoxia; motor defects; neurological function; prenatal hypoxia; rat offspring; sexual differences; spermidine intervention

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Útero / Espermidina / Cognición / Disfunción Cognitiva / Hipoxia Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals / Pregnancy Idioma: En Revista: Acta Pharmacol Sin Asunto de la revista: FARMACOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: China

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