Somatic Evolution in Non-neoplastic IBD-Affected Colon.

Olafsson, Sigurgeir; McIntyre, Rebecca E; Coorens, Tim; Butler, Timothy; Jung, Hyunchul; Robinson, Philip S; Lee-Six, Henry; Sanders, Mathijs A; Arestang, Kenneth; Dawson, Claire; Tripathi, Monika; Strongili, Konstantina; Hooks, Yvette; Stratton, Michael R; Parkes, Miles; Martincorena, Inigo; Raine, Tim; Campbell, Peter J; Anderson, Carl A

Olafsson, Sigurgeir; McIntyre, Rebecca E; Coorens, Tim; Butler, Timothy; Jung, Hyunchul; Robinson, Philip S; Lee-Six, Henry; Sanders, Mathijs A; Arestang, Kenneth; Dawson, Claire; Tripathi, Monika; Strongili, Konstantina; Hooks, Yvette; Stratton, Michael R; Parkes, Miles; Martincorena, Inigo; Raine, Tim; Campbell, Peter J; Anderson, Carl A.

Afiliación

Olafsson S; Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.
McIntyre RE; Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.
Coorens T; Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.
Butler T; Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.
Jung H; Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.
Robinson PS; Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK; University of Cambridge, Department of Paediatrics, Cambridge CB2 0QQ, UK.
Lee-Six H; Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.
Sanders MA; Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK; Department of Hematology, Erasmus University Medical Center, Postbus 2040, 3000 CA Rotterdam, the Netherlands.
Arestang K; Department of Gastroenterology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridgeshire CB2 0QQ, UK.
Dawson C; Department of Gastroenterology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridgeshire CB2 0QQ, UK.
Tripathi M; Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridgeshire CB2 0QQ, UK.
Strongili K; Department of Gastroenterology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridgeshire CB2 0QQ, UK.
Hooks Y; Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.
Stratton MR; Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.
Parkes M; Department of Gastroenterology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridgeshire CB2 0QQ, UK.
Martincorena I; Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.
Raine T; Department of Gastroenterology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridgeshire CB2 0QQ, UK.
Campbell PJ; Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.
Anderson CA; Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK. Electronic address: carl.anderson@sanger.ac.uk.

Cell ; 182(3): 672-684.e11, 2020 08 06.

Article en En | MEDLINE | ID: mdl-32697969

Asunto(s)

Evolución Clonal/genética; Colitis/genética; Enfermedades Inflamatorias del Intestino/genética; Tasa de Mutación; Adulto; Anciano; Anciano de 80 o más Años; Envejecimiento/genética; Evolución Clonal/inmunología; Colitis/metabolismo; Colitis Ulcerosa/genética; Colitis Ulcerosa/metabolismo; Enfermedad de Crohn/genética; Enfermedad de Crohn/metabolismo; Proteínas de Unión al ADN/genética; Células Epiteliales/metabolismo; Células Epiteliales/patología; Proteína 7 que Contiene Repeticiones F-Box-WD/genética; Femenino; Humanos; Mutación INDEL; Enfermedades Inflamatorias del Intestino/inmunología; Enfermedades Inflamatorias del Intestino/metabolismo; Enfermedades Inflamatorias del Intestino/patología; Interleucina-17/metabolismo; Mucosa Intestinal/metabolismo; Mucosa Intestinal/patología; Masculino; Persona de Mediana Edad; Filogenia; Mutación Puntual; Receptores de Superficie Celular/genética; Ribonucleasas/genética; Receptores Toll-Like/genética; Factores de Transcripción/genética; Secuenciación Completa del Genoma

Palabras clave

Crohn's disease; IL17; PIGR; ZC3H12A; inflammatory bowel disease; intestinal epithelia; mutation rate; mutational signatures; somatic mutations; ulcerative colitis

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedades Inflamatorias del Intestino / Colitis / Evolución Clonal / Tasa de Mutación Límite: Aged80 Idioma: En Revista: Cell Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido

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