Over-expression of human PP5 gene in mice induces corneal hyperplasia and leads to ocular surface squamous neoplasia.

Dou, Longyu; Wang, Jun; Deng, Ran; Wang, Chao; Xie, Zhongwen; Yong, Weidong

Dou, Longyu; Wang, Jun; Deng, Ran; Wang, Chao; Xie, Zhongwen; Yong, Weidong.

Afiliación

Dou L; Institute of Laboratory Animal Science, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Wang J; Institute of Laboratory Animal Science, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China; College of Tourism and Culinary Science, Yangzhou University, Yangzhou, Jiangsu, China; College of Life Sciences, Anhui Agricultural University, Hefei, Anhui, China.
Deng R; Institute of Laboratory Animal Science, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Wang C; Institute of Laboratory Animal Science, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Xie Z; College of Life Sciences, Anhui Agricultural University, Hefei, Anhui, China.
Yong W; Institute of Laboratory Animal Science, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. Electronic address: yongwd@hotmail.com.

Biochem Biophys Res Commun ; 529(2): 487-493, 2020 08 20.

Article en En | MEDLINE | ID: mdl-32703456

Asunto(s)

Carcinoma de Células Escamosas/genética; Córnea/patología; Neoplasias del Ojo/genética; Proteínas Nucleares/genética; Fosfoproteínas Fosfatasas/genética; Regulación hacia Arriba; Animales; Carcinoma de Células Escamosas/patología; Proliferación Celular; Córnea/metabolismo; Neoplasias del Ojo/patología; Femenino; Humanos; Hiperplasia/genética; Hiperplasia/patología; Masculino; Ratones; Ratones Endogámicos C57BL; Ratones Transgénicos

Palabras clave

Corneal hyperplasia; FGF-7; Ocular surface squamous neoplasia; Protein phosphatase 5; Transgenic mice; p53

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Nucleares / Carcinoma de Células Escamosas / Regulación hacia Arriba / Fosfoproteínas Fosfatasas / Córnea / Neoplasias del Ojo Límite: Animals / Female / Humans / Male Idioma: En Revista: Biochem Biophys Res Commun Año: 2020 Tipo del documento: Article País de afiliación: China

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