P2X7R promotes angiogenesis and tumour-associated macrophage recruitment by regulating the NF-&#954;B signalling pathway in colorectal cancer cells.

Yang, Chunhui; Shi, Shuang; Su, Ying; Tong, Jing-Shan; Li, Liangjun

P2X7R promotes angiogenesis and tumour-associated macrophage recruitment by regulating the NF-κB signalling pathway in colorectal cancer cells.

Yang, Chunhui; Shi, Shuang; Su, Ying; Tong, Jing-Shan; Li, Liangjun.

Afiliación

Yang C; Department of Clinical Laboratory, the Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Shi S; Department of Clinical Laboratory, the Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Su Y; Department of Clinical Laboratory, the Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Tong JS; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Li L; Department of Clinical Laboratory, the Second Affiliated Hospital of Dalian Medical University, Dalian, China.

J Cell Mol Med ; 24(18): 10830-10841, 2020 09.

Article en En | MEDLINE | ID: mdl-32735377

Asunto(s)

Adenocarcinoma/fisiopatología; Neoplasias Colorrectales/fisiopatología; FN-kappa B/metabolismo; Proteínas de Neoplasias/fisiología; Neovascularización Patológica/fisiopatología; Receptores Purinérgicos P2X7/fisiología; Macrófagos Asociados a Tumores/fisiología; Adenocarcinoma/inmunología; Adenocarcinoma/metabolismo; Adenocarcinoma/patología; Animales; Línea Celular Tumoral; Movimiento Celular; Neoplasias Colorrectales/inmunología; Neoplasias Colorrectales/metabolismo; Neoplasias Colorrectales/patología; Citocinas/metabolismo; Técnicas de Silenciamiento del Gen; Humanos; Ratones; Ratones Endogámicos BALB C; Invasividad Neoplásica; Receptores Purinérgicos P2X7/biosíntesis; Receptores Purinérgicos P2X7/genética; Proteínas Recombinantes/metabolismo; Transducción de Señal/fisiología

Palabras clave

NF-κB; P2X7R; TAMs; angiogenesis; cancer stem cells; tumour growth

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Adenocarcinoma / FN-kappa B / Receptores Purinérgicos P2X7 / Macrófagos Asociados a Tumores / Proteínas de Neoplasias / Neovascularización Patológica Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: J Cell Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2020 Tipo del documento: Article País de afiliación: China

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