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Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma.
Nobre, Liana; Zapotocky, Michal; Khan, Sara; Fukuoka, Kohei; Fonseca, Adriana; McKeown, Tara; Sumerauer, David; Vicha, Ales; Grajkowska, Wieslawa A; Trubicka, Joanna; Li, Kay Ka Wai; Ng, Ho-Keung; Massimi, Luca; Lee, Ji Yeoun; Kim, Seung-Ki; Zelcer, Shayna; Vasiljevic, Alexandre; Faure-Conter, Cécile; Hauser, Peter; Lach, Boleslaw; van Veelen-Vincent, Marie-Lise; French, Pim J; Van Meir, Erwin G; Weiss, William A; Gupta, Nalin; Pollack, Ian F; Hamilton, Ronald L; Nageswara Rao, Amulya A; Giannini, Caterina; Rubin, Joshua B; Moore, Andrew S; Chambless, Lola B; Vibhakar, Rajeev; Ra, Young Shin; Massimino, Maura; McLendon, Roger E; Wheeler, Helen; Zollo, Massimo; Ferruci, Veronica; Kumabe, Toshihiro; Faria, Claudia C; Sterba, Jaroslav; Jung, Shin; López-Aguilar, Enrique; Mora, Jaume; Carlotti, Carlos G; Olson, James M; Leary, Sarah; Cain, Jason; Krskova, Lenka.
Afiliación
  • Nobre L; Division of Haematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada.
  • Zapotocky M; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
  • Khan S; These authors contributed equally.
  • Fukuoka K; Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, University Hospital Motol, Charles University, Prague, Czech Republic.
  • Fonseca A; These authors contributed equally.
  • McKeown T; Monash Children's Cancer Centre, Monash University, Melbourne, VIC, Australia.
  • Sumerauer D; Children's Cancer Centre, Royal Children's Hospital, Murdoch Children's Research Institute, Department of Pediatrics, University of Melbourne, Melbourne, VIC, Australia.
  • Vicha A; Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan.
  • Grajkowska WA; Division of Haematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada.
  • Trubicka J; Division of Haematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada.
  • Li KKW; Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, University Hospital Motol, Charles University, Prague, Czech Republic.
  • Ng HK; Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, University Hospital Motol, Charles University, Prague, Czech Republic.
  • Massimi L; Department of Pathology, The Children's Memorial Health Institute, Warsaw, Poland.
  • Lee JY; Department of Pathology, The Children's Memorial Health Institute, Warsaw, Poland.
  • Kim SK; Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.
  • Zelcer S; Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.
  • Vasiljevic A; Fondazione Policlinico A. Gemelli IRCCS, Catholic University Medical School, Rome, Italy.
  • Faure-Conter C; Department of Neurosurgery, Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul, South Korea.
  • Hauser P; Department of Neurosurgery, Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul, South Korea.
  • Lach B; Division of Pediatric Hematology/Oncology, Western University, London, ON, Canada.
  • van Veelen-Vincent ML; Department of Pathology and Molecular Medicine, Division of Anatomical Pathology, McMaster University, Hamilton, ON, Canada.
  • French PJ; Department of Pediatrics, Institut d'Hemato-Oncologie Pediatrique, Lyon, France.
  • Van Meir EG; Second Department of Pediatrics, Semmelweis University, Budapest, Hungary.
  • Weiss WA; Department of Pathology and Molecular Medicine, Division of Anatomical Pathology, McMaster University and Department of Pathology and Laboratory Medicine, Hamilton General Hospital, Hamilton, ON, Canada.
  • Gupta N; Department of Neurosurgery, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Pollack IF; Department of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Hamilton RL; Departments of Neurosurgery, Hematology, and Medical Oncology, School of Medicine and Winship Cancer Institute, Emory University, Atlanta, GA, USA.
  • Nageswara Rao AA; Departments of Neurological Surgery and Pediatrics, University of California, San Francisco, San Francisco, CA, USA.
  • Giannini C; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
  • Rubin JB; Departments of Neurological Surgery and Pediatrics, University of California, San Francisco, San Francisco, CA, USA.
  • Moore AS; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Chambless LB; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Vibhakar R; Division of Pediatric Hematology/Oncology, Mayo Clinic, Rochester, MN, USA.
  • Ra YS; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
  • Massimino M; Departments of Pediatrics, Anatomy, and Neurobiology, Washington University School of Medicine, St. Louis, MO, USA.
  • McLendon RE; Queensland Children's Medical Research Institute, Children's Health Queensland, Brisbane, QLD, Australia.
  • Wheeler H; Division of Oncology, Children's Health Queensland, Brisbane, QLD, Australia.
  • Zollo M; Department of Neurological Surgery, Vanderbilt Medical Center, Nashville, TN, USA.
  • Ferruci V; Department of Pediatrics, University of Colorado Denver, Aurora, CO, USA.
  • Kumabe T; Department of Neurosurgery, University of Ulsan, Asan Medical Center, Seoul, South Korea.
  • Faria CC; Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
  • Sterba J; Department of Pathology, Duke University, Durham, NC, USA.
  • Jung S; Kolling Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia.
  • López-Aguilar E; Dipartimento di Medicina Molecolare e Biotecnologie Mediche DMMBM, Università di Napoli Federico II, Naples, Italy.
  • Mora J; Dipartimento di Medicina Molecolare e Biotecnologie Mediche DMMBM, Università di Napoli Federico II, Naples, Italy.
  • Carlotti CG; Department of Neurosurgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
  • Olson JM; Division of Neurosurgery, Centro Hospitalar Lisboa Norte, Hospital de Santa Maria, Lisbon, Portugal.
  • Leary S; Department of Pediatric Oncology, School of Medicine, Masaryk University, Brno, Czech Republic.
  • Cain J; Department of Neurosurgery, Chonnam National University Research Institute of Medical Sciences, Chonnam National University Hwasun Hospital and Medical School, Hwasun-gun, Chonnam, South Korea.
  • Krskova L; Division of Pediatric Hematology/Oncology, Hospital Pediatría Centro Médico Nacional Century XXI, Mexico City, Mexico.
Cell Rep Med ; 1(3)2020 06 23.
Article en En | MEDLINE | ID: mdl-32743560
ABSTRACT
Over the past decade, wingless-activated (WNT) medulloblastoma has been identified as a candidate for therapy de-escalation based on excellent survival; however, a paucity of relapses has precluded additional analyses of markers of relapse. To address this gap in knowledge, an international cohort of 93 molecularly confirmed WNT MB was assembled, where 5-year progression-free survival is 0.84 (95%, 0.763-0.925) with 15 relapsed individuals identified. Maintenance chemotherapy is identified as a strong predictor of relapse, with individuals receiving high doses of cyclophosphamide or ifosphamide having only one very late molecularly confirmed relapse (p = 0.032). The anatomical location of recurrence is metastatic in 12 of 15 relapses, with 8 of 12 metastatic relapses in the lateral ventricles. Maintenance chemotherapy, specifically cumulative cyclophosphamide doses, is a significant predictor of relapse across WNT MB. Future efforts to de-escalate therapy need to carefully consider not only the radiation dose but also the chemotherapy regimen and the propensity for metastatic relapses.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Protocolos de Quimioterapia Combinada Antineoplásica / Neoplasias Cerebelosas / Meduloblastoma / Recurrencia Local de Neoplasia Límite: Adolescent / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Cell Rep Med Año: 2020 Tipo del documento: Article País de afiliación: Canadá
Texto completo
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Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Protocolos de Quimioterapia Combinada Antineoplásica / Neoplasias Cerebelosas / Meduloblastoma / Recurrencia Local de Neoplasia Límite: Adolescent / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Cell Rep Med Año: 2020 Tipo del documento: Article País de afiliación: Canadá