Cryo-EM Uncovers Atomic Details for Loading Cell-Killing Enzymes to the Anthrax Toxin Pretranslocation Complex.

ABSTRACT

In this issue of Structure, Zhou et al. report the structures of full-length lethal and edema factors, the cytotoxic components of the deadly anthrax toxin, in complex with the toxin's cell binding and delivery module, the protective antigen prechannel, providing an atomic description for the toxin recruitment prior to translocation.