The use and adherence of oral anticoagulants in Primary Health Care in Catalunya, Spain: A real-world data cohort study.
Aten Primaria
; 52(8): 529-538, 2020 10.
Article
en En
| MEDLINE
| ID: mdl-32788057
ABSTRACT
OBJECTIVE:
We aimed to describe sociodemographic, comorbidities, co-medication and risk of thromboembolic events and bleeding in patients with NVAF initiating oral anticoagulants (OAC) for stroke prevention, and to estimate adherence and persistence to OAC.SETTING:
Primary Health Care (PHC) in the Catalan Health Institute (ICS), Catalunya, Spain.PARTICIPANTS:
All NVAF adult patients initiating OAC for stroke prevention in August 2013-December 2015.METHODS:
Population-based cohort study. Persistence was measured in patients initiating OAC in August 2013-December 2014. DATA SOURCE SIDIAP, which captures electronic health records from PHC in the (ICS), covering approximately 5.8 million people.RESULTS:
51,690 NVAF patients initiated OAC; 47,197 (91.3%) were naive to OAC and 32,404 (62.7%) initiated acenocoumarol. Mean age was 72.8 years (SD 12.3) and 49.4% were women. Platelet-aggregation inhibitors were taken by 9105 (17.6%) of the patients. Persistence and adherence were estimated up to the end of follow-up. For 22,075 patients, persistence was higher among the non-naive patients [n=258 (61.7%)] than among the naive [n=11,502 (53.1%)]. Adherence was estimated for patients initiating DOAC and it was similar in naive and non-naive patients. Among the naive to DOAC treatment, those starting rivaroxaban showed a highest proportion [(n=360 (80.1%)] of good adherence at implementation (MPR>80%) while patients starting dabigatran were less adherent [n=203 (47.8%)].CONCLUSIONS:
Acenocoumarol was the most frequently prescribed OAC as first therapy in NVAF patients. Non-naive to DOAC showed better persistence than naive. Rivaroxaban showed higher proportion of adherent patients during the implementation phase than apixaban and dabigatran the lowest.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fibrilación Atrial
/
Accidente Cerebrovascular
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
País/Región como asunto:
Europa
Idioma:
En
Revista:
Aten Primaria
Año:
2020
Tipo del documento:
Article
País de afiliación:
España