A pedigree-based prediction model identifies carriers of deleterious de novo mutations in families with Li-Fraumeni syndrome.

Gao, Fan; Pan, Xuedong; Dodd-Eaton, Elissa B; Recio, Carlos Vera; Montierth, Matthew D; Bojadzieva, Jasmina; Mai, Phuong L; Zelley, Kristin; Johnson, Valen E; Braun, Danielle; Nichols, Kim E; Garber, Judy E; Savage, Sharon A; Strong, Louise C; Wang, Wenyi

Gao, Fan; Pan, Xuedong; Dodd-Eaton, Elissa B; Recio, Carlos Vera; Montierth, Matthew D; Bojadzieva, Jasmina; Mai, Phuong L; Zelley, Kristin; Johnson, Valen E; Braun, Danielle; Nichols, Kim E; Garber, Judy E; Savage, Sharon A; Strong, Louise C; Wang, Wenyi.

Afiliación

Gao F; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Pan X; Department of Statistics, Rice University, Houston, Texas 77005, USA.
Dodd-Eaton EB; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Recio CV; Department of Statistics, Texas A&M University, College Station, Texas 77843, USA.
Montierth MD; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Bojadzieva J; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Mai PL; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Zelley K; Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, Texas 77030, USA.
Johnson VE; Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Braun D; Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Nichols KE; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Garber JE; Department of Statistics, Texas A&M University, College Station, Texas 77843, USA.
Savage SA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Strong LC; Department of Data Sciences, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
Wang W; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

Genome Res ; 30(8): 1170-1180, 2020 08.

Article en En | MEDLINE | ID: mdl-32817165

Asunto(s)

Neoplasias de la Mama/genética; Predisposición Genética a la Enfermedad/genética; Mutación de Línea Germinal/genética; Síndrome de Li-Fraumeni/genética; Neoplasias Ováricas/genética; Adulto; Proteína BRCA1/genética; Proteína BRCA2/genética; Neoplasias de la Mama/diagnóstico; Familia; Femenino; Humanos; Linaje; Proteína p53 Supresora de Tumor/genética; Adulto Joven

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Neoplasias de la Mama / Síndrome de Li-Fraumeni / Mutación de Línea Germinal / Predisposición Genética a la Enfermedad Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans Idioma: En Revista: Genome Res Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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