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A Phase 1 dose-escalation study to evaluate safety, pharmacokinetics and pharmacodynamics of AsiDNA, a first-in-class DNA repair inhibitor, administered intravenously in patients with advanced solid tumours.
Le Tourneau, Christophe; Delord, Jean-Pierre; Kotecki, Nuria; Borcoman, Edith; Gomez-Roca, Carlos; Hescot, Ségolène; Jungels, Christiane; Vincent-Salomon, Anne; Cockenpot, Vincent; Eberst, Lauriane; Molé, Audrey; Jdey, Wael; Bono, Françoise; Trochon-Joseph, Véronique; Toussaint, Hélène; Zandanel, Christelle; Adamiec, Olga; de Beaumont, Olivier; Cassier, Philippe Alexandre.
Afiliación
  • Le Tourneau C; Department of Drug Development and Innovation (D3i), Institut Curie, Paris and Saint-Cloud, France. christophe.letourneau@curie.fr.
  • Delord JP; Institut Claudius Régaud, IUCT-Oncopole, Toulouse, France.
  • Kotecki N; Medical Oncology Clinic, Institut Jules Bordet, Brussels, Belgium.
  • Borcoman E; Department of Drug Development and Innovation (D3i), Institut Curie, Paris and Saint-Cloud, France.
  • Gomez-Roca C; Institut Claudius Régaud, IUCT-Oncopole, Toulouse, France.
  • Hescot S; Department of Drug Development and Innovation (D3i), Institut Curie, Paris and Saint-Cloud, France.
  • Jungels C; Medical Oncology Clinic, Institut Jules Bordet, Brussels, Belgium.
  • Vincent-Salomon A; Department of Tumor Biology, Institut Curie, Paris, France.
  • Cockenpot V; Department of Tumor Biology, Institut Curie, Paris, France.
  • Eberst L; Medical Oncology, Centre Léon Bérard, Lyon, France.
  • Molé A; Clinical Department, Onxeo, Paris, France.
  • Jdey W; Scientific Department, Onxeo, Paris, France.
  • Bono F; Scientific Department, Onxeo, Paris, France.
  • Trochon-Joseph V; Scientific Department, Onxeo, Paris, France.
  • Toussaint H; Scientific Department, Onxeo, Paris, France.
  • Zandanel C; Scientific Department, Onxeo, Paris, France.
  • Adamiec O; Clinical Department, Onxeo, Paris, France.
  • de Beaumont O; Clinical Department, Onxeo, Paris, France.
  • Cassier PA; Medical Oncology, Centre Léon Bérard, Lyon, France.
Br J Cancer ; 123(10): 1481-1489, 2020 11.
Article en En | MEDLINE | ID: mdl-32839491
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: ADN / Colesterol / Neoplasias Tipo de estudio: Clinical_trials Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Br J Cancer Año: 2020 Tipo del documento: Article País de afiliación: Francia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: ADN / Colesterol / Neoplasias Tipo de estudio: Clinical_trials Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Br J Cancer Año: 2020 Tipo del documento: Article País de afiliación: Francia