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Novel brain permeant mTORC1/2 inhibitors are as efficacious as rapamycin or everolimus in mouse models of acquired partial epilepsy and tuberous sclerosis complex.
Theilmann, Wiebke; Gericke, Birthe; Schidlitzki, Alina; Muneeb Anjum, Syed Muhammad; Borsdorf, Saskia; Harries, Timon; Roberds, Steven L; Aguiar, Dean J; Brunner, Daniela; Leiser, Steven C; Song, Dekun; Fabbro, Doriano; Hillmann, Petra; Wymann, Matthias P; Löscher, Wolfgang.
Afiliación
  • Theilmann W; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Germany.
  • Gericke B; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Germany; Center for Systems Neuroscience, Hannover, Germany.
  • Schidlitzki A; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Germany.
  • Muneeb Anjum SM; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Germany.
  • Borsdorf S; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Germany.
  • Harries T; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Germany.
  • Roberds SL; Tuberous Sclerosis Alliance, Silver Spring, MD, USA.
  • Aguiar DJ; Tuberous Sclerosis Alliance, Silver Spring, MD, USA.
  • Brunner D; PsychoGenics, Paramus, NJ, USA.
  • Leiser SC; PsychoGenics, Paramus, NJ, USA.
  • Song D; PsychoGenics, Paramus, NJ, USA.
  • Fabbro D; PIQUR Therapeutics AG, Basel, Switzerland.
  • Hillmann P; PIQUR Therapeutics AG, Basel, Switzerland.
  • Wymann MP; Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058, Basel, Switzerland.
  • Löscher W; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Germany; Center for Systems Neuroscience, Hannover, Germany. Electronic address: wolfgang.loescher@tiho-hannover.de.
Neuropharmacology ; 180: 108297, 2020 12 01.
Article en En | MEDLINE | ID: mdl-32890589
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Esclerosis Tuberosa / Epilepsias Parciales / Sirolimus / Everolimus / Diana Mecanicista del Complejo 1 de la Rapamicina / Diana Mecanicista del Complejo 2 de la Rapamicina Límite: Animals Idioma: En Revista: Neuropharmacology Año: 2020 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Esclerosis Tuberosa / Epilepsias Parciales / Sirolimus / Everolimus / Diana Mecanicista del Complejo 1 de la Rapamicina / Diana Mecanicista del Complejo 2 de la Rapamicina Límite: Animals Idioma: En Revista: Neuropharmacology Año: 2020 Tipo del documento: Article País de afiliación: Alemania