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Mitoxantrone impairs proteasome activity and prompts early energetic and proteomic changes in HL-1 cardiomyocytes at clinically relevant concentrations.
Costa, Vera Marisa; Capela, João Paulo; Sousa, Joana R; Eleutério, Rute P; Rodrigues, Patrícia R S; Dores-Sousa, José Luís; Carvalho, Rui A; Lourdes Bastos, Maria; Duarte, José Alberto; Remião, Fernando; Almeida, M Gabriela; Varner, Kurt J; Carvalho, Félix.
Afiliación
  • Costa VM; UCIBIO/REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal. veramcosta@ff.up.pt.
  • Capela JP; UCIBIO/REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.
  • Sousa JR; FP-ENAS, Fernando Pessoa Energy, Environment and Health Research Unit, Universidade Fernando Pessoa, Porto, Portugal.
  • Eleutério RP; UCIBIO/REQUIMTE, Faculty of Sciences and Technology, Nova University Lisboa, Monte Caparica, Portugal.
  • Rodrigues PRS; UCIBIO/REQUIMTE, Faculty of Sciences and Technology, Nova University Lisboa, Monte Caparica, Portugal.
  • Dores-Sousa JL; UCIBIO/REQUIMTE, Faculty of Sciences and Technology, Nova University Lisboa, Monte Caparica, Portugal.
  • Carvalho RA; UCIBIO/REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.
  • Lourdes Bastos M; Department of Chemical Engineering, Vrije Universiteit Brussel, Brussels, Belgium.
  • Duarte JA; Faculty of Sciences and Technology, Neurosciences Center of Coimbra, University of Coimbra, Coimbra, Portugal.
  • Remião F; UCIBIO/REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.
  • Almeida MG; CIAFEL, Faculty of Sports, University of Porto, Porto, Portugal.
  • Varner KJ; UCIBIO/REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.
  • Carvalho F; UCIBIO/REQUIMTE, Faculty of Sciences and Technology, Nova University Lisboa, Monte Caparica, Portugal.
Arch Toxicol ; 94(12): 4067-4084, 2020 12.
Article en En | MEDLINE | ID: mdl-32894303
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Mitoxantrona / Proteoma / Miocitos Cardíacos / Proteómica / Complejo de la Endopetidasa Proteasomal / Metabolismo Energético / Cardiopatías Límite: Animals Idioma: En Revista: Arch Toxicol Año: 2020 Tipo del documento: Article País de afiliación: Portugal
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Mitoxantrona / Proteoma / Miocitos Cardíacos / Proteómica / Complejo de la Endopetidasa Proteasomal / Metabolismo Energético / Cardiopatías Límite: Animals Idioma: En Revista: Arch Toxicol Año: 2020 Tipo del documento: Article País de afiliación: Portugal