TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms.

Esparza-Baquer, Aitor; Labiano, Ibone; Sharif, Omar; Agirre-Lizaso, Aloña; Oakley, Fiona; Rodrigues, Pedro M; Zhuravleva, Ekaterina; O'Rourke, Colm J; Hijona, Elizabeth; Jimenez-Agüero, Raul; Riaño, Ioana; Landa, Ana; La Casta, Adelaida; Zaki, Marco Y W; Munoz-Garrido, Patricia; Azkargorta, Mikel; Elortza, Felix; Vogel, Andrea; Schabbauer, Gernot; Aspichueta, Patricia; Andersen, Jesper B; Knapp, Sylvia; Mann, Derek A; Bujanda, Luis; Banales, Jesus Maria; Perugorria, Maria Jesus

Esparza-Baquer, Aitor; Labiano, Ibone; Sharif, Omar; Agirre-Lizaso, Aloña; Oakley, Fiona; Rodrigues, Pedro M; Zhuravleva, Ekaterina; O'Rourke, Colm J; Hijona, Elizabeth; Jimenez-Agüero, Raul; Riaño, Ioana; Landa, Ana; La Casta, Adelaida; Zaki, Marco Y W; Munoz-Garrido, Patricia; Azkargorta, Mikel; Elortza, Felix; Vogel, Andrea; Schabbauer, Gernot; Aspichueta, Patricia; Andersen, Jesper B; Knapp, Sylvia; Mann, Derek A; Bujanda, Luis; Banales, Jesus Maria; Perugorria, Maria Jesus.

Afiliación

Esparza-Baquer A; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, San Sebastian, Spain.
Labiano I; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, San Sebastian, Spain.
Sharif O; Institute for Vascular Biology, Center for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria.
Agirre-Lizaso A; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria.
Oakley F; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, San Sebastian, Spain.
Rodrigues PM; Newcastle Fibrosis Research Group, Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Zhuravleva E; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, San Sebastian, Spain.
O'Rourke CJ; CIBERehd, Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Hijona E; Department of Health and Medical Sciences, Biotech Research & Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark.
Jimenez-Agüero R; Department of Health and Medical Sciences, Biotech Research & Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark.
Riaño I; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, San Sebastian, Spain.
Landa A; CIBERehd, Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
La Casta A; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, San Sebastian, Spain.
Zaki MYW; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, San Sebastian, Spain.
Munoz-Garrido P; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, San Sebastian, Spain.
Azkargorta M; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, San Sebastian, Spain.
Elortza F; Newcastle Fibrosis Research Group, Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Vogel A; Biochemistry Department, Faculty of Pharmacy, Minia University, Minya, Egypt.
Schabbauer G; Department of Health and Medical Sciences, Biotech Research & Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark.
Aspichueta P; CIBERehd, Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Andersen JB; Proteomics Platform, CIC bioGUNE, ProteoRed-ISCIII, Bizkaia Science and Technology Park, Derio, Spain.
Knapp S; CIBERehd, Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Mann DA; Proteomics Platform, CIC bioGUNE, ProteoRed-ISCIII, Bizkaia Science and Technology Park, Derio, Spain.
Bujanda L; Institute for Vascular Biology, Center for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria.
Banales JM; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, Vienna, Austria.
Perugorria MJ; Institute for Vascular Biology, Center for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria.

Gut ; 70(7): 1345-1361, 2021 07.

Article en En | MEDLINE | ID: mdl-32907830

Asunto(s)

Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/metabolismo; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/metabolismo; Glicoproteínas de Membrana/genética; Receptores Inmunológicos/genética; Adulto; Anciano; Animales; Carcinogénesis/genética; Carcinoma Hepatocelular/inducido químicamente; Carcinoma Hepatocelular/patología; Línea Celular Tumoral; Proliferación Celular; Dietilnitrosamina; Femenino; Mutación con Ganancia de Función; Expresión Génica; Células Estrelladas Hepáticas/metabolismo; Hepatitis/metabolismo; Hepatocitos/patología; Hepatocitos/fisiología; Humanos; Hígado/metabolismo; Cirrosis Hepática/metabolismo; Neoplasias Hepáticas/inducido químicamente; Neoplasias Hepáticas/patología; Regeneración Hepática/genética; Regeneración Hepática/fisiología; Macrófagos/metabolismo; Masculino; Glicoproteínas de Membrana/metabolismo; Ratones; Ratones Noqueados; Persona de Mediana Edad; Estrés Oxidativo; Factores Protectores; ARN/metabolismo; Especies Reactivas de Oxígeno/metabolismo; Receptores Inmunológicos/metabolismo; Esferoides Celulares; Regulación hacia Arriba; Proteínas Wnt/metabolismo; Vía de Señalización Wnt; Proteína Wnt3/metabolismo

Palabras clave

hepatocellular carcinoma; immune-mediated liver damage; liver immunology; liver regeneration; molecular carcinogenesis

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Glicoproteínas de Membrana / Receptores Inmunológicos / Carcinoma Hepatocelular / Neoplasias Hepáticas Tipo de estudio: Prognostic_studies Idioma: En Revista: Gut Año: 2021 Tipo del documento: Article País de afiliación: España

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