From tobacco smoking to cancer mutational signature: a mediation analysis strategy to explore the role of epigenetic changes.

Chen, Zhishan; Wen, Wanqing; Cai, Qiuyin; Long, Jirong; Wang, Ying; Lin, Weiqiang; Shu, Xiao-Ou; Zheng, Wei; Guo, Xingyi

From tobacco smoking to cancer mutational signature: a mediation analysis strategy to explore the role of epigenetic changes.

Chen, Zhishan; Wen, Wanqing; Cai, Qiuyin; Long, Jirong; Wang, Ying; Lin, Weiqiang; Shu, Xiao-Ou; Zheng, Wei; Guo, Xingyi.

Afiliación

Chen Z; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, 37203, USA.
Wen W; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, 37203, USA. wanqing.wen@vumc.org.
Cai Q; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, 37203, USA.
Long J; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, 37203, USA.
Wang Y; The Kidney Disease Center, the First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, 310029, China.
Lin W; The Kidney Disease Center, the First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, 310029, China.
Shu XO; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, 37203, USA.
Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, 37203, USA.
Guo X; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, 37203, USA. xingyi.guo@vumc.org.

BMC Cancer ; 20(1): 880, 2020 Sep 14.

Article en En | MEDLINE | ID: mdl-32928150

Asunto(s)

Metilación de ADN/efectos de los fármacos; Epigénesis Genética/genética; Neoplasias/genética; Fumar Tabaco/efectos adversos; Islas de CpG/efectos de los fármacos; Metilación de ADN/genética; Epigénesis Genética/efectos de los fármacos; Femenino; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Genoma Humano/efectos de los fármacos; Humanos; Masculino; Análisis de Mediación; Mutación/genética; Proteínas de Neoplasias/genética; Neoplasias/sangre; Neoplasias/inducido químicamente; Neoplasias/patología

Palabras clave

Gene expression; Mediation analysis; Methylation; Mutational signature; Tobacco smoking

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Metilación de ADN / Epigénesis Genética / Fumar Tabaco / Neoplasias Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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