Long-Term Inhalative Sedation in Children With Pulmonary Diseases.
J Intensive Care Med
; 36(11): 1305-1312, 2021 Nov.
Article
en En
| MEDLINE
| ID: mdl-32938279
ABSTRACT
OBJECTIVES:
To describe safety and feasibility of long-term inhalative sedation (LTIS) in children with severe respiratory diseases compared to patients with normal lung function with respect to recent studies that showed beneficial effects in adult patients with acute respiratory distress syndrome (ARDS).DESIGN:
Single-center retrospective study.SETTING:
12-bed pediatric intensive care unit (PICU) in a tertiary-care academic medical center in Germany. PATIENTS All patients treated in our PICU with LTIS using the AnaConDa® device between July 2011 and July 2019. MEASUREMENTS AND MAINRESULTS:
Thirty-seven courses of LTIS in 29 patients were analyzed. LTIS was feasible in both groups, but concomitant intravenous sedatives could be reduced more rapidly in children with lung diseases. Cardiocirculatory depression requiring vasopressors was observed in all patients. However, severe side effects only rarely occured.CONCLUSIONS:
In this largest cohort of children treated with LTIS reported so far, LTIS was feasible even in children with severely impaired lung function. From our data, a prospective trial on the use of LTIS in children with ARDS seems justified. However, a thorough monitoring of cardiocirculatory side effects is mandatory.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Síndrome de Dificultad Respiratoria
/
Anestésicos por Inhalación
Tipo de estudio:
Observational_studies
Límite:
Child
/
Humans
Idioma:
En
Revista:
J Intensive Care Med
Asunto de la revista:
TERAPIA INTENSIVA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Alemania