Health State Utility Values in Schizophrenia: A Systematic Review and Meta-Analysis.
Value Health
; 23(9): 1256-1267, 2020 09.
Article
en En
| MEDLINE
| ID: mdl-32940244
ABSTRACT
OBJECTIVES:
Patient preferences are increasingly important in informing clinical and policy decisions. Health-state utility values (HSUVs) are quantitative measures of people's preferences over different health states. In schizophrenia, there is no clarity about HSUVs across the symptoms' severity spectrum. This meta-analysis aims to synthesize the literature on HSUVs in people with schizophrenia.METHODS:
We searched Medline, PsycInfo, Embase, EconLit, The Cochrane Library, and specialized databases. The studies reporting HSUVs in people with schizophrenia were selected and pooled in a random-effects meta-analysis. The primary outcome was the mean HSUV obtained from participants.RESULTS:
A total of 54 studies involving 87 335 participants were included. The pooled estimate using direct elicitation was a mean HSUV of 0.79 (95% CI 0.70-0.88) for mild symptomatic states, 0.69 (95% CI 0.54-0.85) in moderate states, and 0.34 (95% CI 0.13-0.56) in severe states. Studies using indirect techniques resulted in a pooled mean HSUV of 0.73 (95% CI 0.67-0.78) applying the EuroQol 5-dimension, 0.66 (95% CI 0.62-0.71) in the Short-Form 6-dimension, and 0.59 (95% CI 0.57-0.61) using the Quality of Well-Being scale. All the estimates resulted in considerable heterogeneity, partially reduced by meta-regression.CONCLUSION:
Our findings suggest that the severity of psychotic symptoms has an important effect on HSUVs in schizophrenia, with values mirroring patients with disabling physical conditions such as cancer and stroke. Decision makers should be aware of these results when including people's preferences in trials, models, and policy decisions.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Calidad de Vida
/
Esquizofrenia
/
Indicadores de Salud
/
Prioridad del Paciente
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Value Health
Asunto de la revista:
FARMACOLOGIA
Año:
2020
Tipo del documento:
Article