Malignant melanoma arising in a primary mediastinal germ cell tumor.
Pathol Res Pract
; 216(11): 153210, 2020 Nov.
Article
en En
| MEDLINE
| ID: mdl-32950894
ABSTRACT
Primary mediastinal germ cell tumors with somatic malignancies are rare. We report a case of a 34-year old man with melanoma arising in a primary mediastinal mixed germ cell tumor. On initial biopsy, the patient was found to have a germ cell tumor containing yolk sac and embryonal components only. After chemotherapy, histopathological evaluation of the residual tumor in the wide local resection specimen revealed a mature teratoma with melanoma. Molecular studies demonstrated that the residual germ cell tumor harbored KIT and NRAS mutations associated with malignant melanoma.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Teratoma
/
Neoplasias Primarias Secundarias
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Neoplasias del Mediastino
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Melanoma
Límite:
Adult
/
Humans
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Male
Idioma:
En
Revista:
Pathol Res Pract
Año:
2020
Tipo del documento:
Article