Alternative Options for Skin Cancer Therapy via Regulation of AKT and Related Signaling Pathways.
Int J Mol Sci
; 21(18)2020 Sep 18.
Article
en En
| MEDLINE
| ID: mdl-32962182
ABSTRACT
Global environmental pollution has led to human exposure to ultraviolet (UV) radiation due to the damaged ozone layer, thereby increasing the incidence and death rate of skin cancer including both melanoma and non-melanoma. Overexpression and activation of V-akt murine thymoma viral oncogene homolog (AKT, also known as protein kinase B) and related signaling pathways are major factors contributing to many cancers including lung cancer, esophageal squamous cell carcinoma and skin cancer. Although BRAF inhibitors are used to treat melanoma, further options are needed due to treatment resistance and poor efficacy. Depletion of AKT expression and activation, and related signaling cascades by its inhibitors, decreases the growth of skin cancer and metastasis. Here we have focused the effects of AKT and related signaling (PI3K/AKT/mTOR) pathways by regulators derived from plants and suggest the need for efficient treatment in skin cancer therapy.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Plantas Medicinales
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Neoplasias Cutáneas
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Extractos Vegetales
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Inhibidores de Proteínas Quinasas
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Proteínas Proto-Oncogénicas c-akt
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Melanoma
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Antineoplásicos
Límite:
Animals
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Humans
Idioma:
En
Revista:
Int J Mol Sci
Año:
2020
Tipo del documento:
Article