Impact of Obesity on Voriconazole Pharmacokinetics among Pediatric Hematopoietic Cell Transplant Recipients.

Takahashi, Takuto; Smith, Angela R; Jacobson, Pamala A; Fisher, James; Rubin, Nathan T; Kirstein, Mark N

Takahashi, Takuto; Smith, Angela R; Jacobson, Pamala A; Fisher, James; Rubin, Nathan T; Kirstein, Mark N.

Afiliación

Takahashi T; Division of Hematology and Oncology, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
Smith AR; Division of Blood and Marrow Transplant, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
Jacobson PA; Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.
Fisher J; Division of Blood and Marrow Transplant, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
Rubin NT; Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.
Kirstein MN; Clinical Pharmacology Analytical Services, University of Minnesota, Minneapolis, Minnesota, USA.

Antimicrob Agents Chemother ; 64(12)2020 11 17.

Article en En | MEDLINE | ID: mdl-32988816

Asunto(s)

Antifúngicos; Trasplante de Células Madre Hematopoyéticas; Obesidad; Receptores de Trasplantes; Voriconazol; Adolescente; Antifúngicos/uso terapéutico; Niño; Preescolar; Citocromo P-450 CYP2C19/genética; Humanos; Masculino; Obesidad/complicaciones; Voriconazol/farmacocinética; Adulto Joven

Palabras clave

CYP2C19; obesity; pharmacogenomics; voriconazole; voriconazole N-oxide

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trasplante de Células Madre Hematopoyéticas / Voriconazol / Receptores de Trasplantes / Antifúngicos / Obesidad Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Child / Child, preschool / Humans / Male Idioma: En Revista: Antimicrob Agents Chemother Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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